Evaluation of Patients With HAM/TSP
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Objective: Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) is a rare neurologic disorder that affects less than 5% of patients infected with the HTLV-I virus. The purpose of this protocol is to study the natural history of HAM/TSP by monitoring clinical progression of patients longitudinally. Additionally, we will attempt to define the virological and immunological changes of HAM/TSP. Study Population: Patients with HAM/TSP who fulfill World Health Organization diagnostic criteria are eligible to participate in this protocol. Asymptomatic seropositive individuals and individuals with indeterminate HTLV-1 serology are also eligible to participate. Design and Outcome Measures: A longitudinal assessment of clinical, virological and immunological progression in HAM/TSP will be accomplished through periodic testing and evaluation. Asymptomatic seropositive individuals, those with seroindeterminate HTLV-I serology and normal volunteers may serve as controls. Longitudinal standardized neurological examinations will be performed. Longitudinal samples of serum, plasma, and lymphocytes may be obtained from participants. Lumbar punctures may be performed on all participants. These samples will be used virological and immunological assays. A focus is on the relationships between the characteristics of viral infection, the immune response, and the genetic makeup.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby z potwierdzonym zakażeniem wirusem HTLV (testy ELISA i Western blot pozytywne).
- •Osoby z częściowo potwierdzonym zakażeniem wirusem HTLV (test ELISA pozytywny, Western blot niejednoznaczny).
- •Osoby, które miały kontakt z kimś zakażonym HTLV (np. rodzina, partner).
- •Osoby zdrowe chętne do pomocy w badaniu.
- •Chęć uczestniczenia w badaniu i jego procedurach.
✗ Disqualifies
- •Brak chęci lub możliwość uczestniczenia w badaniu i jego procedurach.
- •Stan zdrowia, który zdaniem lekarza może zagrażać bezpieczeństwu pacjenta lub utrudniać udział w badaniu.
- •Osoby poniżej 18 roku życia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 120 Years
- Last updated (source)
- July 14, 2026
- Sex
- No restrictions
Locations (1)
National Institutes of Health Clinical Center
Bethesda, United States
Trial contact
Daniel S Reich, M.D.
Steven Jacobson, Ph.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.