Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2. to increase the biological understanding of key observations made by our clinical researchers; 3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent z potwierdzonym zapaleniem przełyku Barretta (widocznym podczas badania endoskopowego)
- •Pacjent z nowotworem przełyku
- •Krewny pacjenta z zapaleniem przełyku Barretta lub nowotworem przełyku
- •Wiek 18 lat lub więcej
- •Wiek poniżej 18 lat - ze zgodą rodzica lub opiekuna
- •Zdolność do wyrażenia świadomej zgody na udział w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Johns Hopkins Hospital
Baltimore, United States
Mayo Clinic
Rochester, United States
Washington University School of Medicine
St Louis, United States
Columbia University Medical Center
New York, United States
University of North Carolina at Chapel Hill
Chapel Hill, United States
University Hospitals of Cleveland
Cleveland, United States
Cleveland Clinic
Cleveland, United States
University of Pennsylvania
Philadelphia, United States
VA Puget Sound Health Care System
Seattle, United States
Fred Hutchinson Cancer Research Center, UWMC
Seattle, United States
Trial contact
Amitabh Chak, MD
Wendy Brock, RN
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/11/2026.
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