Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to learn more about the effects of your BRCA mutation on the ovaries. The BRCA gene can make it hard to conceive a child in the future. It may also bring on early menopause. The researchers will check blood levels of hormones that the ovaries produce. The hormones that researchers will check are anti-Mullerian hormone (AMH), estradiol and follicle stimulating hormone (FSH). The researchers will do this before, during, and after cancer treatment. The researchers will also ask you to fill out questionnaires about your menstrual cycle (your periods) and information about your health and pregnancies. This may help us learn which women will be more likely to have early menopause.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18-45 lat (dla kobiet z rakiem piersi) lub 25-45 lat (dla kobiet z mutacją BRCA)
- •Kobieta przed menopauzą
- •Regularne miesiączki (cykl 21-35 dni)
- •Rozpoznany rak piersi stadium 0-III (dla grupy I) lub potwierdzona mutacja BRCA (dla grupy II)
- •Planowana chemioterapia lub hormonoterapia (dla grupy I)
- •Co najmniej 10 naturalnych cykli miesiączkowych w ciągu ostatniego roku
- •Bez wcześniejszych zabiegów na jajnikach
- •Bez wcześniejszej chemioterapii
✗ Disqualifies
- •Brak regularnych miesiączek
- •Więcej niż jeden nieregularny cykl miesiączkowy w ciągu ostatniego roku (z wyjątkami dla kobiet w ciąży)
- •Wcześniejsza chemioterapia
- •Wcześniejsza operacja lub choroba jajników
- •PCOS (zespół policystycznych jajników)
- •Hormonalna antykoncepcja w ciągu ostatnich 4 tygodni
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 44 Years
- Last updated (source)
- October 16, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (8)
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
New York Presbyterian Hospital-Weill Medical College of Cornell University
New York, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Trial contact
Shari Goldfarb, MD
Minna Lee, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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