Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a multi-center, sequential cohort, open-label, volume and dose escalation study of the safety, tolerability, and distribution of 186RNL given by convection enhanced delivery to patients with recurrent or progressive malignant glioma after standard surgical, radiation, and/or chemotherapy treatment. The study uses a modified Fibonacci dose escalation, followed by an expansion at the maximum tolerated dose (MTD) to determine efficacy. The starting absorbed dose is 1mCi in a volume of 0.660mL.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony histologicznie glejak III lub IV stopnia, który wrócił lub pogorszył się po leczeniu
- •Wcześniejsze leczenie standardowe (operacja, chemioterapia lub radioterapia)
- •Stan ogólny pacjenta pozwalający na udział w badaniu (ECOG 0-2 lub Karnofsky ≥60)
- •Spodziewana długość życia co najmniej 2 miesiące
- •Prawidłowe funkcje wątroby, nerek i morfologia krwi
- •Kobiety w wieku rozrodczym muszą mieć ujemny test ciąży; wszyscy uczestnicy muszą stosować antykoncepcję
- •Stabilna dawka leków przeciwpadaczkowych przez co najmniej 2 tygodnie przed badaniem
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (4)
Northshore University Hospital
Manhasset, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
UT Southwestern Medical Center
Dallas, United States
The Cancer Therapy and Research Center at UTHSCSA
San Antonio, United States
Trial contact
Eric Daniels
Andrew Brenner, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/16/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.