Multicenter Trial for Eliminating Breast Cancer Surgery or Radiotherapy in Exceptional Responders to Neoadjuvant Systemic Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This clinical trial studies eliminating surgery and/or radiation therapy in treating breast cancer patients. In HER2 positive and triple negative breast cancers, after systemic therapy, when image-guided biopsy shows no residual cancer, patients then receive standard breast radiotherapy with no surgery. In ER positive/HER2 negative breast cancers, after endocrine therapy and ablative radiotherapy, when image-guided biopsy shows no residual cancer, patients then receive standard endocrine therapy with no surgery. For patients who have HER2 positive and triple negative breast cancers and standard surgery, after systemic therapy, breast radiotherapy is being eliminated when the pathology from surgery shows no residual cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie rak piersi w jednym miejscu, rozmiar guza do 5 cm, do 4 zmian w węzłach chłonnych, bez przerzutów odległych
- •Typ raka: HER2-dodatni lub potrójnie ujemny (dla kohorty A) lub ER/PR-dodatni HER2-ujemny (dla kohorty B)
- •Pacjentka chce zachować pierś - operacja oszczędzająca
- •Wiek 40 lat lub więcej
- •Płeć żeńska
- •Jeśli wcześniejszy nowotwór inny niż rak piersi - musi być całkowicie wyleczony i brak cech choroby
- •Badanie ultrasound węzłów chłonnych wykazało nie więcej niż 4 podejrzane węzły
- •Rozmiar guza przed procedurą biopsji maksymalnie 2 cm
Simplified criteria — AI translation
Trial details
- Minimum age
- 30 Years
- Last updated (source)
- March 9, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (8)
MD Anderson Cancer Center - Banner
Gilbert, United States
Baptist MD Anderson Cancer Center
Jacksonville, United States
Queen's Medical Center
Honolulu, United States
Mayo Clinic
Rochester, United States
Cooper Hospital Univ Med Ctr, MD Anderson at Cooper Voorhees
Voorhees Township, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
M D Anderson Cancer Center
Houston, United States
Trial contact
Henry Kuerer
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.