Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies the side effects and how well combination chemotherapy works in treating patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, Burkitt lymphoma/leukemia, or double-hit lymphoma/leukemia that has come back or does not respond to treatment. Drugs used in chemotherapy, such as clofarabine, etoposide, cyclophosphamide, vincristine sulfate liposome, dexamethasone and bortezomib, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Białaczka limfoblastyczna lub chłoniak limfoblastyczny, który wrócił lub nie reaguje na leczenie
- •Wiek powyżej 15 lat
- •Co najmniej 21 dni od poprzedniej chemioterapii (lub 14 dni w przypadku szybko rosnących nowotworów)
- •Funkcja wątroby: bilirubina do 1,5 mg/dL
- •Funkcja wątroby: transaminaza SGPT do 3-krotności normy
- •Funkcja nerek: czyszczenie kreatyniny co najmniej 50 mL/min
- •Ogólny stan zdrowia pozwalający na leczenie (skala ECOG do 3)
- •Podpisana świadoma zgoda na udział w badaniu
✗ Disqualifies
- •Ciężkie uszkodzenie nerwów obwodowych (stopień 3 lub wyższy)
- •Czynna choroba przeszczepienia przeciwko gospodarzowi w wątrobie
- •Zakażenie wirusem zapalenia wątroby B lub C
- •Ciąża lub karmienie piersią
Simplified criteria — AI translation
Trial details
- Minimum age
- 15 Years
- Last updated (source)
- August 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
M D Anderson Cancer Center
Houston, United States
Trial contact
Maro Ohanian
Maro Ohanian
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/11/2026.
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