Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The main purpose of this study is to: * Learn about the safety of ubamatamab and to find out what dose of ubamatamab can be given alone or with cemiplimab to patients with ovarian cancer or cancer of the uterus * The study will also look at the levels of ubamatamab and/or cemiplimab in the body and measure how well the body can remove the study drug(s). This is called pharmacokinetics * The study will also look at any signs that ubamatamab alone or with cemiplimab can treat recurrent advanced ovarian cancer or cancer of the uterus * To find out how safe and tolerable pretreatment is in combination with ubamatamab and to see how well it works to prevent or minimize Cytokine Release Syndrome (CRS)
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza zaawansowanego raka jajnika, raka otrzewnej lub raka jajowodu
- •Wcześniejsze leczenie platynią lub niemożność stosowania platyny
- •Nawrót lub pogorszenie się choroby po ostatnim leczeniu
- •Brak innych skutecznych opcji leczenia
- •Prawidłowa funkcja organów i szpiku kostnego
- •Spodziewana długość życia co najmniej 3 miesiące
- •W przypadku raka macicy: potwierdzony rak macicy, który pogorszył się po immunoterapii i chemioterapii platynowej
✗ Disqualifies
- •Wcześniejsze leczenie immunoterapią (PD-1/PD-L1)
- •Wcześniejsze leczenie lekami kierowanymi na MUC16
- •Niezbadany lub aktywny nowotwór mózgu lub przerzuty do mózgu
- •Poważne problemy z sercem lub nadciśnieniem
- •Więcej niż 4 wcześniejsze linie chemioterapii (w kohortach raka jajnika)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (52)
University of Alabama_6th Ave
Birmingham, United States
Massachusetts General Hospital
Boston, United States
Dana Farber / Harvard Cancer Center
Boston, United States
Mayo Clinic - Rochester
Rochester, United States
Roswell Park Cancer Institute
Buffalo, United States
Columbia University Medical Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
The Ohio State University Wexner Medical Center
Columbus, United States
Stephenson Cancer Center
Oklahoma City, United States
Sarah Cannon Research Institute
Nashville, United States
Virginia Commonwealth University
Richmond, United States
Prince of Wales Hospital
Randwick, Australia
Peter MacCallum Cancer Center
Melbourne, Australia
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
Grand Hopital de Charleroi
Charleroi, Belgium
UZLeuven
Leuven, Belgium
Hopital Lyon Sud
Pierre-Bénite, France
Centre Georges Francois Leclerc
Dijon, France
Institut Bergonie
Bordeaux, France
Centre Francois Baclesse (CFB)
Caen, France
Centre Antoine Lacassagne
Nice, France
Institut Gustave Roussy
Villejuif, France
Rambam Health Care Campus
Haifa, Israel
Sharet Institute of Oncology
Jerusalem, Israel
Sheba Medical Center
Tel Litwinsky, Israel
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
Humanitas S. Pio X
Milan, Italy
Istituto Europeo di Oncologia
Milan, Italy
Instituto Nazionale Tumori- Fondazione Pascale
Naples, Italy
Radboudumc
Nijmegen, Netherlands
Erasmus MC
Rotterdam, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Yonsei University Health System
Seoul, South Korea
Asan Medical Center, Univ. of Ulsan
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Clinica Universidad de Navarra
Pamplona, Spain
Institut Catala dOncologia Badalona
Badalona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Institut Catala d'Oncologia
Barcelona, Spain
Clinica Universidad Navarra (CUN) Madrid
Madrid, Spain
Fundacion Jimenez Diaz
Madrid, Spain
Hospital Universitario San Carlos
Madrid, Spain
Hospital Clinico Universitatio Santiago de Compostela
Santiago de Compostela, Spain
University of Oxford
Oxford, United Kingdom
Royal Marsden Hospital - Sutton
Sutton, United Kingdom
The Royal Marsden NHS Foundation Trust
Sutton, United Kingdom
University College London Hospitals
London, United Kingdom
Guys Hospital
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Trial contact
Clinical Trials Administrator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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