Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Neoadjuvant therapy has been widely applied to locally advanced rectal cancer. However, about 50% of patients receiving this therapy do not respond well as evidenced by the fact that their T or N stages are not effectively decreased judged by postoperative pathological examination. The purpose of this trail is to identify the biomarkers (from within patients' tumor mass before neoadjuvant therapy) to predict resistance to neoadjuvant therapy. These biomarkers can help stratify neoadjuvant-resistant patients towards surgery while avoiding unnecessary chemoradio-based neoadjuvant therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony przez badanie histopatologiczne rak gruczołowy odbytnicy
- •Guz znajduje się w odbytnicy poniżej 12 cm od odbytnika
- •Zaawansowana postać nowotworu (stadium II-III wg skali TNM)
- •Pacjent nigdy wcześniej nie otrzymywał chemioterapii, radioterapii ani immunoterapii
- •Pacjent wyraża świadomą zgodę na uczestnictwo w badaniu
✗ Disqualifies
- •Niedrożność jelit lub jej zagrożenie, lub perforacja jelit
- •Historia innych nowotworów w ciągu ostatnich 5 lat
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Locations (2)
Wuhan Union Hospital
Wuhan, China
Hubei Cancer Hospital
Wuhan, China
Trial contact
Zheng Wang, MD/PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.
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