Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Patients are in 2 cohorts: Cohort 1: dexamethasone, methotrexate, ifosfamide, pegaspargase, and etoposide (modified SMILE) chemotherapy regimen alone and pembrolizumab in children, adolescents, and young adults with advanced stage NK lymphoma and leukemia Cohort 2: combining pralatrexate (PRX) (Cycles 1, 2, 4, 6) and brentuximab vedotin (BV) (Cycles 3, 5) to cyclophosphamide, doxorubicin, and prednisone in children, adolescent, and young adults with advanced peripheral T-cell lymphoma (non-anaplastic large cell lymphoma or non-NK lymphoma/leukemia) . Both groups proceed to allogeneic stem cell transplant with disease response.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Waga co najmniej 10 kilogramów w momencie włączenia do badania
- •Nowo zdiagnozowany chłoniak NK lub białaczka NK (grupa 1) lub zaawansowany chłoniak T-komórkowy (grupa 2)
- •Stadium III lub IV (zaawansowana choroba)
- •Prawidłowa funkcja wątroby i serca
- •Prawidłowa funkcja płuc (bez duszności w spoczynku)
✗ Disqualifies
- •Chłoniak z dużymi komórkami anaplastycznymi (typ ALCL)
- •Rozprzestrzenienie się choroby na mózg i rdzeń kręgowy
- •Stadium I lub II (choroba wcześniejsza)
- •Poprzednia chemioterapia z powodu tego samego nowotworu
- •Poprzednia radioterapia lub leczenie sterydami, chyba że w stanach nagłych
Simplified criteria — AI translation
Trial details
- Minimum age
- 1 Year
- Maximum age
- 31 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (6)
University of Alabama
Birmingham, United States
Children's Hospital Orange County
Orange, United States
University of California San Francisco
San Francisco, United States
Helen De Vos
Grand Rapids, United States
New York Medical College
Valhalla, United States
Nationwide Children's Hospital
Columbus, United States
Trial contact
Ana Xavier
Lauren Harrison
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.
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