WIRE - Novel Treatments in Renal Cell Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Evaluation of proof of mechanism with relation to ktrans and/or CD8 count when different IMPs are given as monotherapy or as combination therapy. These would be administered in the "window of opportunity", prior to nephrectomy in surgically resectable renal cell cancer
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby w wieku 18 lat lub starsze.
- •Przewidywany czas życia wynosi co najmniej 16 tygodni.
- •Potwierdzony rak nerkowokomórkowy (RCC) w badaniu biopsji.
- •Guz nerek, który można usunąć operacyjnie.
- •Istnienie co najmniej jednej widocznej zmiany nowotworowej, która może być dokładnie zmierzona.
✗ Disqualifies
- •Nie można brać udziału, jeśli wcześniej przyjmowano pewne leki, takie jak inhibitory PARP, inhibitory kinazy tyrozynowej, leki immunoterapeutyczne ani inhibitory mTOR.
- •Nie można brać udziału, jeśli wcześniej stosowano terapię interferonem lub interleukiną.
- •Nie można brać udziału w badaniu, jeśli leczono raka przy użyciu cytostatyków.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 25, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
Addenbrooke's Hospital
Cambridge, United Kingdom
Western General Hospital, Edinburgh, EH4 2XU
Edinburgh, United Kingdom
Royal Devon University Healthcare NHSFT, Exeter, EX2 5DW
Exeter, United Kingdom
Beatson Institute for Cancer Research
Glasgow, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE
Oxford, United Kingdom
Weston Park Hospital
Sheffield, United Kingdom
Trial contact
CCTU Cancer Theme
Sulekha Said
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/26/2026.
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