Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant. Sometimes the transplanted white blood cells from a donor attack the body's normal tissues (called graft versus host disease). Removing a particular type of T cell (naive T cells) from the donor cells before the transplant may stop this from happening.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent ma białaczkę (np. ALL lub AML) lub inne podobne schorzenie krwi.
- •Pacjent ma od 6 miesięcy do 26 lat.
- •Znaleziono zgodnego dawcę komórek macierzystych (z rodziny lub niespokrewnionego).
- •Ogólny stan zdrowia pacjenta jest dobry (wynik punktowy Karnofsky'ego lub Lanskiego >= 60%).
- •Serce pacjenta działa prawidłowo (frakcja wyrzutowa lewej komory >= 40%).
- •Płuca pacjenta funkcjonują dobrze (zdolność dyfuzyjna dla tlenku węgla >= 60% lub saturacja tlenem >= 92% na powietrzu).
- •Poziom bilirubiny we krwi jest w normie (chyba że jest to spowodowane chorobą lub lekami).
Simplified criteria — AI translation
Trial details
- Minimum age
- 6 Months
- Maximum age
- 26 Years
- Last updated (source)
- July 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Children's Hospital of Los Angeles
Los Angeles, United States
Children's National Medical Center
Washington D.C., United States
Children's Healthcare of Atlanta
Atlanta, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
Dana Farber / Boston Children's Hospital
Boston, United States
UH Rainbow Babies and Children's Hospital (University Hospitals Cleveland Medical Center)
Cleveland, United States
Cleveland Clinic Foundation
Cleveland, United States
Oregon Health and Science University
Portland, United States
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, United States
Fred Hutch/University of Washington Cancer Consortium
Seattle, United States
Trial contact
Marie Bleakley
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/31/2026.
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