Men at High Genetic Risk for Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Background: Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk for prostate cancer. Objectives: To study men with specific genetic changes and determine who is at higher risk for getting prostate cancer. To study if certain genetic changes and family history can be used to help prevent or treat prostate cancer. Eligibility: Males between ages 30-75 who have one or more specific genetic changes but without prostate cancer. Design: * This study does not perform genetic testing. All participants must have documented genetic changes and able to provide a copy of the report. * Before enrollment, participants will provide a copy of documented genetic changes and go through a telephone interview to determine eligibility for the study. * On enrollment, participants will have medical and family history review, medication review, physical exam, blood collection for clinical and research testing, and MRI (magnetic resonance imaging) of the prostate. * Every year, participants will repeat the physical exam, medical history, family history, medication review, routine blood tests, including PSA and testosterone. * Every 2 years, participants will repeat all the above plus prostate MRI and blood tests for research. * If, at any time, the physical exam, blood tests or MRI are abnormal, participants may be asked to do a biopsy. * If the biopsy results in prostate cancer, participants will be given counseling on next steps, general treatment recommendations, and then followed with a phone call each year. * Participants may ask to speak with a genetic counselor....
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Mężczyźni w wieku od 30 do 75 lat.
- •Posiadają udokumentowane zmiany genetyczne związane z ryzykiem raka prostaty, potwierdzone przez certyfikowane laboratorium.
- •Mogą przedstawić kopię raportu z badaniem genetycznym.
- •Potrafią zrozumieć i zgadzają się na udział w badaniu.
✗ Disqualifies
- •Mężczyźni, u których wcześniej zdiagnozowano lub leczono raka prostaty.
- •Przeciwwskazania do rezonansu magnetycznego (np. rozrusznik serca, alergia na środek kontrastowy).
- •Inne choroby, które mogą zwiększać ryzyko lub uniemożliwiać świadomą zgodę.
Simplified criteria — AI translation
Trial details
- Minimum age
- 30 Years
- Maximum age
- 75 Years
- Last updated (source)
- July 23, 2026
- Sex
- Male only
Locations (1)
National Institutes of Health Clinical Center
Bethesda, United States
Trial contact
Anna C Couvillon, C.R.N.P.
Fatima H Karzai, M.D.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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