RecruitingPhase IIIEN originalLeukemia

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy and immunotherapy (chemo-immunotherapy) for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. Inotuzumab ozogamicin is a monoclonal antibody, which is a type of protein that can bind to certain targets on the surface of cells. Inotuzumab ozogamicin is a monoclonal antibody that is linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells by binding to the CD22 protein on the surface of the cancer cell and delivering calicheamicin inside the cells to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Blinatumomab is a specialized type of monoclonal antibody known as a bispecific T-cell engager (BiTE). It works by simultaneously binding to CD19 on cancer cells and CD3 on normal immune cells, bringing them together to destroy leukemia cells. Blinatumomab is a standard part of chemo-immunotherapy treatment for B-ALL. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin or blinatumomab. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemo-immunotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first phase of therapy: Induction. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-induction treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (consolidation, blinatumomab block 1, interim maintenance 1, blinatumomab block 2, delayed intensification, interim maintenance 2, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of consolidation or part of delayed intensification. Other aims of this study include evaluating 1) side effects of treatment using patient-reported outcomes and health-related quality of life, 2) the best ways to help patients adhere to oral chemotherapy regimens, 3) the relationship between levels of inotuzumab ozogamicin in the blood and side effects, 4) the impact of chemo-immunotherapy on the immune system and risk of infection, and 5) the impact of social determinants of health on outcomes. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek powyżej 1 roku i poniżej 25 lat
  • Nowo zdiagnozowana białaczka limfoblastyczna typu B lub mieszana ostra białaczka
  • Obecność białaczki w szpiku kostnym (ponad 25% nowotworowych komórek)
  • Dla dzieci w wieku 1-10 lat: wysoka liczba białych ciałek krwi (powyżej 50 000) lub białaczka w ośrodkowym układzie nerwowym, jądrach lub wcześniejsze leczenie sterydami
  • Dla pacjentów w wieku 10-25 lat: dowolna liczba białych ciałek krwi
  • Dla białaczki chłoniaka: zaawansowany stadium (III lub IV)
  • Zarejestrownie w wstępnym badaniu APEC14B1 (dla pacjentów z białaczką limfoblastyczną i mieszaną)

Simplified criteria — AI translation

Trial details

Minimum age
365 Days
Maximum age
25 Years
Last updated (source)
July 16, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (231)

Children's Hospital of Alabama

Birmingham, United States

USA Health Strada Patient Care Center

Mobile, United States

Providence Alaska Medical Center

Anchorage, United States

Banner Children's at Desert

Mesa, United States

Phoenix Childrens Hospital

Phoenix, United States

Banner University Medical Center - Tucson

Tucson, United States

Arkansas Children's Hospital

Little Rock, United States

Kaiser Permanente Downey Medical Center

Downey, United States

City of Hope Comprehensive Cancer Center

Duarte, United States

Loma Linda University Medical Center

Loma Linda, United States

Miller Children's and Women's Hospital Long Beach

Long Beach, United States

Children's Hospital Los Angeles

Los Angeles, United States

Cedars-Sinai Medical Center

Los Angeles, United States

Mattel Children's Hospital UCLA

Los Angeles, United States

Valley Children's Hospital

Madera, United States

UCSF Benioff Children's Hospital Oakland

Oakland, United States

Kaiser Permanente-Oakland

Oakland, United States

Children's Hospital of Orange County

Orange, United States

Lucile Packard Children's Hospital Stanford University

Palo Alto, United States

Sutter Medical Center Sacramento

Sacramento, United States

University of California Davis Comprehensive Cancer Center

Sacramento, United States

Rady Children's Hospital - San Diego

San Diego, United States

Naval Medical Center -San Diego

San Diego, United States

UCSF Medical Center-Mission Bay

San Francisco, United States

Santa Barbara Cottage Hospital

Santa Barbara, United States

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Torrance, United States

Children's Hospital Colorado

Aurora, United States

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, United States

Connecticut Children's Medical Center

Hartford, United States

Yale University

New Haven, United States

Alfred I duPont Hospital for Children

Wilmington, United States

MedStar Georgetown University Hospital

Washington D.C., United States

Children's National Medical Center

Washington D.C., United States

Broward Health Medical Center

Fort Lauderdale, United States

Golisano Children's Hospital of Southwest Florida

Fort Myers, United States

UF Health Cancer Institute - Gainesville

Gainesville, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, United States

Nemours Children's Clinic-Jacksonville

Jacksonville, United States

Palms West Radiation Therapy

Loxahatchee Groves, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, United States

Nicklaus Children's Hospital

Miami, United States

Miami Cancer Institute

Miami, United States

AdventHealth Orlando

Orlando, United States

Arnold Palmer Hospital for Children

Orlando, United States

Nemours Children's Hospital

Orlando, United States

Nemours Children's Clinic - Pensacola

Pensacola, United States

Sacred Heart Hospital

Pensacola, United States

Johns Hopkins All Children's Hospital

St. Petersburg, United States

Tampa General Hospital

Tampa, United States

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, United States

Saint Mary's Medical Center

West Palm Beach, United States

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, United States

Augusta University Medical Center

Augusta, United States

Atrium Health Navicent

Macon, United States

Memorial Health University Medical Center

Savannah, United States

Kapiolani Medical Center for Women and Children

Honolulu, United States

Saint Luke's Cancer Institute - Boise

Boise, United States

Lurie Children's Hospital-Chicago

Chicago, United States

University of Illinois

Chicago, United States

University of Chicago Comprehensive Cancer Center

Chicago, United States

Loyola University Medical Center

Maywood, United States

Advocate Children's Hospital-Oak Lawn

Oak Lawn, United States

Advocate Children's Hospital-Park Ridge

Park Ridge, United States

OSF Children's Hospital of Illinois

Peoria, United States

Southern Illinois University School of Medicine

Springfield, United States

Northwestern Medicine Central DuPage Hospital

Winfield, United States

Riley Hospital for Children

Indianapolis, United States

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, United States

Blank Children's Hospital

Des Moines, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, United States

Wesley Medical Center

Wichita, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

Norton Children's Hospital

Louisville, United States

Children's Hospital New Orleans

New Orleans, United States

Ochsner Medical Center Jefferson

New Orleans, United States

Eastern Maine Medical Center

Bangor, United States

Maine Children's Cancer Program

Scarborough, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, United States

Sinai Hospital of Baltimore

Baltimore, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, United States

Walter Reed National Military Medical Center

Bethesda, United States

Tufts Children's Hospital

Boston, United States

Massachusetts General Hospital Cancer Center

Boston, United States

Dana-Farber Cancer Institute

Boston, United States

Baystate Medical Center

Springfield, United States

UMass Memorial Medical Center - University Campus

Worcester, United States

C S Mott Children's Hospital

Ann Arbor, United States

Children's Hospital of Michigan

Detroit, United States

Henry Ford Health Saint John Hospital

Detroit, United States

Michigan State University

East Lansing, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, United States

Bronson Methodist Hospital

Kalamazoo, United States

Corewell Health Children's

Royal Oak, United States

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, United States

University of Minnesota/Masonic Cancer Center

Minneapolis, United States

Mayo Clinic in Rochester

Rochester, United States

University of Mississippi Medical Center

Jackson, United States

University of Missouri Children's Hospital

Columbia, United States

Children's Mercy Hospitals and Clinics

Kansas City, United States

Cardinal Glennon Children's Medical Center

St Louis, United States

Washington University School of Medicine

St Louis, United States

Mercy Hospital Saint Louis

St Louis, United States

Children's Hospital and Medical Center of Omaha

Omaha, United States

University of Nebraska Medical Center

Omaha, United States

University Medical Center of Southern Nevada

Las Vegas, United States

Sunrise Hospital and Medical Center

Las Vegas, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, United States

Summerlin Hospital Medical Center

Las Vegas, United States

Renown Regional Medical Center

Reno, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Hackensack University Medical Center

Hackensack, United States

Morristown Medical Center

Morristown, United States

Jersey Shore Medical Center

Neptune City, United States

Saint Peter's University Hospital

New Brunswick, United States

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, United States

Newark Beth Israel Medical Center

Newark, United States

Saint Joseph's Regional Medical Center

Paterson, United States

Presbyterian Hospital

Albuquerque, United States

University of New Mexico Cancer Center

Albuquerque, United States

Albany Medical Center

Albany, United States

Maimonides Medical Center

Brooklyn, United States

Roswell Park Cancer Institute

Buffalo, United States

NYU Langone Hospital - Long Island

Mineola, United States

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, United States

Mount Sinai Hospital

New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, United States

Memorial Sloan Kettering Cancer Center

New York, United States

NYP/Weill Cornell Medical Center

New York, United States

University of Rochester

Rochester, United States

Stony Brook University Medical Center

Stony Brook, United States

State University of New York Upstate Medical University

Syracuse, United States

Montefiore Medical Center - Moses Campus

The Bronx, United States

New York Medical College

Valhalla, United States

Mission Hospital

Asheville, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, United States

Novant Health Presbyterian Medical Center

Charlotte, United States

Duke University Medical Center

Durham, United States

East Carolina University

Greenville, United States

Wake Forest University Health Sciences

Winston-Salem, United States

Sanford Broadway Medical Center

Fargo, United States

Children's Hospital Medical Center of Akron

Akron, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, United States

Rainbow Babies and Childrens Hospital

Cleveland, United States

Cleveland Clinic Foundation

Cleveland, United States

Nationwide Children's Hospital

Columbus, United States

Dayton Children's Hospital

Dayton, United States

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Natalie Warren Bryant Cancer Center at Saint Francis

Tulsa, United States

Legacy Emanuel Children's Hospital

Portland, United States

Oregon Health and Science University

Portland, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, United States

Geisinger Medical Center

Danville, United States

Penn State Children's Hospital

Hershey, United States

Children's Hospital of Philadelphia

Philadelphia, United States

Saint Christopher's Hospital for Children

Philadelphia, United States

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, United States

Rhode Island Hospital

Providence, United States

Medical University of South Carolina

Charleston, United States

Prisma Health Richland Hospital

Columbia, United States

BI-LO Charities Children's Cancer Center

Greenville, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, United States

T C Thompson Children's Hospital

Chattanooga, United States

East Tennessee Childrens Hospital

Knoxville, United States

The Children's Hospital at TriStar Centennial

Nashville, United States

Vanderbilt University/Ingram Cancer Center

Nashville, United States

Texas Tech University Health Sciences Center-Amarillo

Amarillo, United States

Dell Children's Medical Center of Central Texas

Austin, United States

Driscoll Children's Hospital

Corpus Christi, United States

Medical City Dallas Hospital

Dallas, United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, United States

El Paso Children's Hospital

El Paso, United States

Cook Children's Medical Center

Fort Worth, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, United States

UT MD Anderson Cancer Center

Houston, United States

Covenant Children's Hospital

Lubbock, United States

UMC Cancer Center / UMC Health System

Lubbock, United States

Vannie Cook Children's Clinic

McAllen, United States

Children's Hospital of San Antonio

San Antonio, United States

Methodist Children's Hospital of South Texas

San Antonio, United States

University of Texas Health Science Center at San Antonio

San Antonio, United States

Scott and White Memorial Hospital

Temple, United States

Primary Children's Hospital

Salt Lake City, United States

University of Vermont and State Agricultural College

Burlington, United States

University of Virginia Cancer Center

Charlottesville, United States

Inova Fairfax Hospital

Falls Church, United States

Children's Hospital of The King's Daughters

Norfolk, United States

Naval Medical Center - Portsmouth

Portsmouth, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

Carilion Children's

Roanoke, United States

Seattle Children's Hospital

Seattle, United States

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, United States

Mary Bridge Children's Hospital and Health Center

Tacoma, United States

Madigan Army Medical Center

Tacoma, United States

West Virginia University Charleston Division

Charleston, United States

Edwards Comprehensive Cancer Center

Huntington, United States

West Virginia University Healthcare

Morgantown, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Marshfield Medical Center-Marshfield

Marshfield, United States

Children's Hospital of Wisconsin

Milwaukee, United States

John Hunter Children's Hospital

Hunter Regional Mail Centre, Australia

The Children's Hospital at Westmead

Westmead, Australia

Queensland Children's Hospital

South Brisbane, Australia

Women's and Children's Hospital-Adelaide

North Adelaide, Australia

Royal Hobart Hospital

Saint Hobart, Australia

Monash Medical Center-Clayton Campus

Clayton, Australia

Royal Children's Hospital

Parkville, Australia

Perth Children's Hospital

Perth, Australia

Alberta Children's Hospital

Calgary, Canada

University of Alberta Hospital

Edmonton, Canada

British Columbia Children's Hospital

Vancouver, Canada

CancerCare Manitoba

Winnipeg, Canada

Janeway Child Health Centre

St. John's, Canada

IWK Health Centre

Halifax, Canada

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Canada

Kingston Health Sciences Centre

Kingston, Canada

Children's Hospital

London, Canada

Children's Hospital of Eastern Ontario

Ottawa, Canada

Hospital for Sick Children

Toronto, Canada

The Montreal Children's Hospital of the MUHC

Montreal, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Canada

Jim Pattison Children's Hospital

Saskatoon, Canada

Saskatoon Cancer Centre

Saskatoon, Canada

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, Canada

Starship Children's Hospital

Grafton, New Zealand

Christchurch Hospital

Christchurch, New Zealand

HIMA San Pablo Oncologic Hospital

Caguas, Puerto Rico

University Pediatric Hospital

San Juan, Puerto Rico

Trial contact

Matthew A. Kutny

PRINCIPAL_INVESTIGATOR

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Hamayun Imran

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Brenda J. Wittman

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Joseph C. Torkildson

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Dana B. Salzberg

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Holly E. Pariury

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Michael W. Bishop

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Robert M. Cooper

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Anna B. Pawlowska

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Albert Kheradpour

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Jacqueline N. Casillas

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Jamie L. Stokke

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Nicole M. Baca

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Ruetima Titapiwatanakun

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Aarati V. Rao

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Elyssa M. Rubin

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Jay Michael S. Balagtas

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Sandra Baril

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Marcio H. Malogolowkin

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William D. Roberts

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Yoko T. Udaka

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Shivani Upadhyay

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Kelly W. Maloney

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Florence Choo

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Michael S. Isakoff

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Farzana Pashankar

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Sridhi Patel

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Jeffrey S. Dome

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Hector M. Rodriguez-Cortes

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Emad K. Salman

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Brian Stover

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Maggie E. Fader

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Fouad M. Hajjar

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Jaime M. Libes-Bander

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Jeffrey H. Schwartz

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Jennifer B. Dean

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Matthew D. Ramirez

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Ryan J. Summers

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Sushmita Nair

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Andrew L. Pendleton

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Wade T. Kyono

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Sara Zarnegar-Lumley

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Dipti S. Dighe

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Rebecca E. McFall

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Sandeep Batra

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Bassem I. Razzouk

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Andrew P. Groves

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James T. Badgett

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Michael J. Ferguson

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Maria C. Velez-Yanguas

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Craig Lotterman

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Daniel L. Callaway

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Eric C. Larsen

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Teresa A. York

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Jason M. Fixler

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Stacy L. Cooper

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Kip R. Hartman

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Alison M. Friedmann

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Melissa A. Burns

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Joshua W. Goldman

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Alissa M. Martin

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Kathleen Y. Butler

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Marie V. Nelson

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Michael K. Richards

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Peter M. Gordon

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Madeleine O'Keefe

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Amanda Strobel

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Barbara A. Gruner

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William S. Ferguson

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Kristin Zorn

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Robin D. Hanson

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Jill C. Beck

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Alan K. Ikeda

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Seema L. Rao

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Angela Ricci

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Jing Chen

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Kathryn L. Laurie

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Nibal A. Zaghloul

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Marissa Botwinick

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Teena Bhatla

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Alissa Kahn

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Beeling Armijo

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Lauren R. Weintraub

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Mahmut Y. Celiker

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Clare J. Twist

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Chana L. Glasser

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Arlene S. Redner

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Elizabeth A. Raetz

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Pamela R. Merola

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Nobuko Hijiya

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Kavitha Ramaswamy

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Jaclyn Rosenzweig

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Rafi R. Kazi

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Melanie A. Comito

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Alice Lee

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Andrew J. Bellantoni

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Douglas J. Scothorn

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Thomas B. Alexander

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Joel A. Kaplan

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Jessica M. Sun

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Sarah Supples

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Erin Wright

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Erin H. Breese

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Duncan S. Stearns

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Matteo M. Trucco

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Mark A. Ranalli

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Jordan M. Wright

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Jamie L. Dargart

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Jill A. Salo

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Jason M. Glover

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Bill H. Chang

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Jacob A. Troutman

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Lisa M. McGregor

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Gregory E. Halligan

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Bradley DeNardo

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Jacqueline M. Kraveka

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Stuart L. Cramer

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Aniket Saha

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Kayelyn J. Wagner

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