Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies the side effects and how well Vyxeos works in treating patients with intermediate and high-risk acute myeloid leukemia who have failed an initial cycle of standard cytarabine and daunorubicin chemotherapy. Vyxeos is a combination of both chemotherapy drugs cytarabine and daunorubicin contained in a liposome. Drugs used in chemotherapy, such as cytarabine and daunorubicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cytarabine and daunorubicin given together in liposomes may have fewer side effects and work better than cytarabine and daunorubicin given alone in patients with acute myeloid leukemia.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznana białaczka szpikowa (ostra białaczka mieloidalna)
- •Poprzednie leczenie chemią standardową (cytarabina i daunorubicyna) w ciągu 14-33 dni przed badaniem
- •Choroba wciąż obecna po pierwszym leczeniu (potwierdzonym badaniem szpiku kostnego)
- •Lekarze uważają, że pacjent nie osiągnie wyleczenia bez dalszego leczenia
- •Pacjent powinien tolerować intensywną chemioterapię
- •Prawidłowe funkcjonowanie serca (frakcja wyrzutowa ≥50%)
- •Całkowita poprzednia dawka daunorubicyny poniżej 462 mg/m²
- •Zdolność do wyrażenia świadomej zgody na uczestnictwo
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- September 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (2)
UC Davis Comprehensive Cancer Center
Sacramento, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Trial contact
The Ohio State University Comprehensive Cancer Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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