Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to find out whether the study drug, TSR-042, followed by standard chemoradiotherapy (the chemotherapy drug capecitabine + radiation therapy) and standard surgery is an effective treatment for advanced dMMR solid tumors. The study will also look at the safety of the study drug.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony histologicznie zaawansowany nowotwór litý lub rak endometrium
- •Nowotwór odpowiadający do leczenia chemioterapią i radioterapią lub operacją
- •Brak przerzutów odległych (rozprzestrzenienia się raka)
- •Guź wykazujący defekt w naprawie DNA potwierdzonej badaniem laboratoryjnym
- •Dla kobiet w wieku rozrodczym: ujemny test ciąży i zgoda na stosowanie antykoncepcji przez cały okres badania
- •Zdolność do samodzielnego funkcjonowania w życiu codziennym (0-1 w skali ECOG)
- •Chęć i możliwość podpisania świadomej zgody na udział w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Hartford Healthcare (Data Collection)
Hartford, United States
Baptist Alliance MCI (Data Collection Only)
Miami, United States
Memorial Sloan Kettering Basking Ridge - Limited Protocol Activities
Basking Ridge, United States
Memorial Sloan Kettering Monmouth - Limited Protocol Activities
Middletown, United States
Memorial Sloan Kettering Bergen - Limited Protocol Activities
Montvale, United States
Memorial Sloan Kettering Commack - Limited Protocol Activities
Commack, United States
Memorial Sloan Kettering Westchester - Limited Protocol Activities
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau - Limited Protocol Activities
Uniondale, United States
Lehigh Valley Health Network (Data Collection Only)
Allentown, United States
Trial contact
Andrea Cercek, MD
Neil Segal, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/16/2026.
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