RecruitingPhase I/IIEN original

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase I/II trial studies the safety, side effects and best dose of M3814 and to see how well it works when given together with radiation therapy in treating patients with pancreatic cancer that has spread to nearby tissue or lymph nodes (locally advanced). M3814 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving M3814 and hypofractionated radiation therapy together may be safe, tolerable and/or more effective than radiation therapy alone in treating patients with locally advanced pancreatic cancer.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony rozpoznaniem raka trzustki (adenocarcinoma)
  • Ukończony 4-6 miesięcy chemioterapii (FOLFIRINOX, NALIRIFOX lub gemcitabine/Abraxane)
  • Zaawansowany rak trzustki z rozprzestrzenieniem się do pobliskich naczyń lub tkanek
  • Wiek co najmniej 18 lat
  • Ogólny stan zdrowia pozwalający na leczenie (skala ECOG 0-2)
  • Wystarczająca liczba białych krwinek i innych parametrów krwi
  • Guz możliwy do zmierzenia na badaniach obrazowych
  • Zatwierdzenie kwalifikacji przez zespół lekarzy specjalistów

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 22, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (44)

City of Hope Comprehensive Cancer Center

Duarte, United States

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, United States

City of Hope at Irvine Lennar

Irvine, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, United States

University of California Davis Comprehensive Cancer Center

Sacramento, United States

UCHealth University of Colorado Hospital

Aurora, United States

Sibley Memorial Hospital

Washington D.C., United States

Northwestern University

Chicago, United States

University of Kansas Clinical Research Center

Fairway, United States

HaysMed

Hays, United States

University of Kansas Cancer Center

Kansas City, United States

Lawrence Memorial Hospital

Lawrence, United States

The University of Kansas Cancer Center - Olathe

Olathe, United States

University of Kansas Cancer Center-Overland Park

Overland Park, United States

Mercy Hospital Pittsburg

Pittsburg, United States

Salina Regional Health Center

Salina, United States

University of Kansas Health System Saint Francis Campus

Topeka, United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

Wayne State University/Karmanos Cancer Institute

Detroit, United States

Weisberg Cancer Treatment Center

Farmington Hills, United States

University Health Truman Medical Center

Kansas City, United States

University of Kansas Cancer Center - North

Kansas City, United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, United States

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Saint Barnabas Medical Center

Livingston, United States

Monmouth Medical Center

Long Branch, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, United States

Roswell Park Cancer Institute

Buffalo, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, United States

Mount Sinai Hospital

New York, United States

NYP/Weill Cornell Medical Center

New York, United States

Montefiore Medical Center-Einstein Campus

The Bronx, United States

Montefiore Medical Center - Moses Campus

The Bronx, United States

Wake Forest University at Clemmons

Clemmons, United States

Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, United States

Wake Forest University Health Sciences

Winston-Salem, United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, United States

Vanderbilt University/Ingram Cancer Center

Nashville, United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Trial contact

Vincent Chung

PRINCIPAL_INVESTIGATOR

Site Public Contact

Farshid Dayyani

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Edward J. Kim

PRINCIPAL_INVESTIGATOR

Site Public Contact

Sarah L. Davis

PRINCIPAL_INVESTIGATOR

Michael J. Pishvaian

PRINCIPAL_INVESTIGATOR

Anup K. Kasi Loknath Kumar

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Matthew P. Deek

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Karyn A. Goodman

PRINCIPAL_INVESTIGATOR

Site Public Contact

Allyson J. Ocean

PRINCIPAL_INVESTIGATOR

Site Public Contact

Janie Y. Zhang

PRINCIPAL_INVESTIGATOR

Emma C. Fields

PRINCIPAL_INVESTIGATOR

Monica A. Patel

PRINCIPAL_INVESTIGATOR

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.

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