RecruitingPhase IIIEN originalLeukemia

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs used in chemotherapy, such as daunorubicin, cytarabine, and gemtuzumab ozogamicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. CPX-351 is made up of daunorubicin and cytarabine and is made in a way that makes the drugs stay in the bone marrow longer and could be less likely to cause heart problems than traditional anthracycline drugs, a common class of chemotherapy drug. Some acute myeloid leukemia patients have an abnormality in the structure of a gene called FLT3. Genes are pieces of DNA (molecules that carry instructions for development, functioning, growth and reproduction) inside each cell that tell the cell what to do and when to grow and divide. FLT3 plays an important role in the normal making of blood cells. This gene can have permanent changes that cause it to function abnormally by making cancer cells grow. Gilteritinib may block the abnormal function of the FLT3 gene that makes cancer cells grow. The overall goals of this study are, 1) to compare the effects, good and/or bad, of CPX-351 with daunorubicin and cytarabine on people with newly diagnosed AML to find out which is better, 2) to study the effects, good and/or bad, of adding gilteritinib to AML therapy for patients with high amounts of FLT3/ITD or other FLT3 mutations and 3) to study changes in heart function during and after treatment for AML. Giving CPX-351 and/or gilteritinib with standard chemotherapy may work better in treating patients with acute myeloid leukemia compared to standard chemotherapy alone.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek poniżej 22 lat w momencie włączenia do badania
  • Nowo zdiagnozowana białaczka ostra (według klasyfikacji WHO z 2016 roku)
  • Co najmniej 20% zmutowanych komórek w szpiku kostnym (lub mniej, ale z obecnością charakterystycznych zmian genetycznych)
  • Dla grupy C: obecność mutacji FLT3/ITD
  • Dla grupy C: brak wrodzonej długiego QT lub bloku serca
  • Dla grupy C: kobiety muszą stosować antykoncepcję przez co najmniej 6 miesięcy po leczeniu gilteritinibem
  • Dla grupy C: mężczyźni muszą stosować antykoncepcję przez co najmniej 4 miesiące po leczeniu gilteritinibem

✗ Disqualifies

  • Dla grupy C: karmiące kobiety nie mogą karmić piersią podczas leczenia i przez 2 miesiące po leczeniu

Simplified criteria — AI translation

Trial details

Maximum age
21 Years
Last updated (source)
July 16, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (205)

Children's Hospital of Alabama

Birmingham, United States

USA Health Strada Patient Care Center

Mobile, United States

Banner Children's at Desert

Mesa, United States

Phoenix Childrens Hospital

Phoenix, United States

Banner University Medical Center - Tucson

Tucson, United States

Arkansas Children's Hospital

Little Rock, United States

Kaiser Permanente Downey Medical Center

Downey, United States

City of Hope Comprehensive Cancer Center

Duarte, United States

Loma Linda University Medical Center

Loma Linda, United States

Miller Children's and Women's Hospital Long Beach

Long Beach, United States

Children's Hospital Los Angeles

Los Angeles, United States

Cedars-Sinai Medical Center

Los Angeles, United States

Mattel Children's Hospital UCLA

Los Angeles, United States

Valley Children's Hospital

Madera, United States

UCSF Benioff Children's Hospital Oakland

Oakland, United States

Kaiser Permanente-Oakland

Oakland, United States

Children's Hospital of Orange County

Orange, United States

Lucile Packard Children's Hospital Stanford University

Palo Alto, United States

University of California Davis Comprehensive Cancer Center

Sacramento, United States

Rady Children's Hospital - San Diego

San Diego, United States

UCSF Medical Center-Mission Bay

San Francisco, United States

Santa Barbara Cottage Hospital

Santa Barbara, United States

Children's Hospital Colorado

Aurora, United States

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center

Denver, United States

Connecticut Children's Medical Center

Hartford, United States

Yale University

New Haven, United States

Alfred I duPont Hospital for Children

Wilmington, United States

MedStar Georgetown University Hospital

Washington D.C., United States

Children's National Medical Center

Washington D.C., United States

Broward Health Medical Center

Fort Lauderdale, United States

Golisano Children's Hospital of Southwest Florida

Fort Myers, United States

UF Health Cancer Institute - Gainesville

Gainesville, United States

Memorial Regional Hospital/Joe DiMaggio Children's Hospital

Hollywood, United States

Nemours Children's Clinic-Jacksonville

Jacksonville, United States

Palms West Radiation Therapy

Loxahatchee Groves, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, United States

Nicklaus Children's Hospital

Miami, United States

AdventHealth Orlando

Orlando, United States

Arnold Palmer Hospital for Children

Orlando, United States

Nemours Children's Hospital

Orlando, United States

Nemours Children's Clinic - Pensacola

Pensacola, United States

Sacred Heart Hospital

Pensacola, United States

Johns Hopkins All Children's Hospital

St. Petersburg, United States

Tampa General Hospital

Tampa, United States

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, United States

Saint Mary's Medical Center

West Palm Beach, United States

Children's Healthcare of Atlanta - Arthur M Blank Hospital

Atlanta, United States

Augusta University Medical Center

Augusta, United States

Memorial Health University Medical Center

Savannah, United States

Kapiolani Medical Center for Women and Children

Honolulu, United States

Saint Luke's Cancer Institute - Boise

Boise, United States

Lurie Children's Hospital-Chicago

Chicago, United States

University of Illinois

Chicago, United States

University of Chicago Comprehensive Cancer Center

Chicago, United States

Loyola University Medical Center

Maywood, United States

Advocate Children's Hospital-Oak Lawn

Oak Lawn, United States

Advocate Children's Hospital-Park Ridge

Park Ridge, United States

OSF Children's Hospital of Illinois

Peoria, United States

Southern Illinois University School of Medicine

Springfield, United States

Riley Hospital for Children

Indianapolis, United States

Ascension Saint Vincent Indianapolis Hospital

Indianapolis, United States

Blank Children's Hospital

Des Moines, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, United States

University of Kentucky/Markey Cancer Center

Lexington, United States

Norton Children's Hospital

Louisville, United States

Children's Hospital New Orleans

New Orleans, United States

Ochsner Medical Center Jefferson

New Orleans, United States

Eastern Maine Medical Center

Bangor, United States

Maine Children's Cancer Program

Scarborough, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, United States

Sinai Hospital of Baltimore

Baltimore, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, United States

Walter Reed National Military Medical Center

Bethesda, United States

Tufts Children's Hospital

Boston, United States

Massachusetts General Hospital Cancer Center

Boston, United States

Dana-Farber Cancer Institute

Boston, United States

UMass Memorial Medical Center - University Campus

Worcester, United States

C S Mott Children's Hospital

Ann Arbor, United States

Children's Hospital of Michigan

Detroit, United States

Henry Ford Health Saint John Hospital

Detroit, United States

Michigan State University

East Lansing, United States

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, United States

Bronson Methodist Hospital

Kalamazoo, United States

Corewell Health Children's

Royal Oak, United States

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, United States

University of Minnesota/Masonic Cancer Center

Minneapolis, United States

Mayo Clinic in Rochester

Rochester, United States

University of Mississippi Medical Center

Jackson, United States

University of Missouri Children's Hospital

Columbia, United States

Children's Mercy Hospitals and Clinics

Kansas City, United States

Cardinal Glennon Children's Medical Center

St Louis, United States

Washington University School of Medicine

St Louis, United States

Mercy Hospital Saint Louis

St Louis, United States

Children's Hospital and Medical Center of Omaha

Omaha, United States

University of Nebraska Medical Center

Omaha, United States

University Medical Center of Southern Nevada

Las Vegas, United States

Sunrise Hospital and Medical Center

Las Vegas, United States

Alliance for Childhood Diseases/Cure 4 the Kids Foundation

Las Vegas, United States

Summerlin Hospital Medical Center

Las Vegas, United States

Renown Regional Medical Center

Reno, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Hackensack University Medical Center

Hackensack, United States

Morristown Medical Center

Morristown, United States

Saint Peter's University Hospital

New Brunswick, United States

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, United States

Newark Beth Israel Medical Center

Newark, United States

Saint Joseph's Regional Medical Center

Paterson, United States

University of New Mexico Cancer Center

Albuquerque, United States

Albany Medical Center

Albany, United States

Maimonides Medical Center

Brooklyn, United States

Roswell Park Cancer Institute

Buffalo, United States

NYU Langone Hospital - Long Island

Mineola, United States

The Steven and Alexandra Cohen Children's Medical Center of New York

New Hyde Park, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, United States

Mount Sinai Hospital

New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, United States

Memorial Sloan Kettering Cancer Center

New York, United States

NYP/Weill Cornell Medical Center

New York, United States

University of Rochester

Rochester, United States

Stony Brook University Medical Center

Stony Brook, United States

State University of New York Upstate Medical University

Syracuse, United States

Montefiore Medical Center - Moses Campus

The Bronx, United States

New York Medical College

Valhalla, United States

Mission Hospital

Asheville, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, United States

Novant Health Presbyterian Medical Center

Charlotte, United States

Duke University Medical Center

Durham, United States

East Carolina University

Greenville, United States

Wake Forest University Health Sciences

Winston-Salem, United States

Sanford Broadway Medical Center

Fargo, United States

Children's Hospital Medical Center of Akron

Akron, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, United States

Rainbow Babies and Childrens Hospital

Cleveland, United States

Cleveland Clinic Foundation

Cleveland, United States

Nationwide Children's Hospital

Columbus, United States

Dayton Children's Hospital

Dayton, United States

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital

Toledo, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Legacy Emanuel Children's Hospital

Portland, United States

Oregon Health and Science University

Portland, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, United States

Geisinger Medical Center

Danville, United States

Penn State Children's Hospital

Hershey, United States

Children's Hospital of Philadelphia

Philadelphia, United States

Saint Christopher's Hospital for Children

Philadelphia, United States

Children's Hospital of Pittsburgh of UPMC

Pittsburgh, United States

Rhode Island Hospital

Providence, United States

Medical University of South Carolina

Charleston, United States

Prisma Health Richland Hospital

Columbia, United States

BI-LO Charities Children's Cancer Center

Greenville, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, United States

T C Thompson Children's Hospital

Chattanooga, United States

East Tennessee Childrens Hospital

Knoxville, United States

The Children's Hospital at TriStar Centennial

Nashville, United States

Vanderbilt University/Ingram Cancer Center

Nashville, United States

Dell Children's Medical Center of Central Texas

Austin, United States

Driscoll Children's Hospital

Corpus Christi, United States

Medical City Dallas Hospital

Dallas, United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, United States

El Paso Children's Hospital

El Paso, United States

Cook Children's Medical Center

Fort Worth, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, United States

UT MD Anderson Cancer Center

Houston, United States

Children's Hospital of San Antonio

San Antonio, United States

Methodist Children's Hospital of South Texas

San Antonio, United States

University of Texas Health Science Center at San Antonio

San Antonio, United States

Scott and White Memorial Hospital

Temple, United States

Primary Children's Hospital

Salt Lake City, United States

University of Vermont and State Agricultural College

Burlington, United States

University of Virginia Cancer Center

Charlottesville, United States

Inova Fairfax Hospital

Falls Church, United States

Children's Hospital of The King's Daughters

Norfolk, United States

Naval Medical Center - Portsmouth

Portsmouth, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

Carilion Children's

Roanoke, United States

Seattle Children's Hospital

Seattle, United States

Providence Sacred Heart Medical Center and Children's Hospital

Spokane, United States

Mary Bridge Children's Hospital and Health Center

Tacoma, United States

Madigan Army Medical Center

Tacoma, United States

West Virginia University Charleston Division

Charleston, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Marshfield Medical Center-Marshfield

Marshfield, United States

Children's Hospital of Wisconsin

Milwaukee, United States

Sydney Children's Hospital

Randwick, Australia

The Children's Hospital at Westmead

Westmead, Australia

Queensland Children's Hospital

South Brisbane, Australia

Perth Children's Hospital

Perth, Australia

Alberta Children's Hospital

Calgary, Canada

University of Alberta Hospital

Edmonton, Canada

British Columbia Children's Hospital

Vancouver, Canada

CancerCare Manitoba

Winnipeg, Canada

IWK Health Centre

Halifax, Canada

McMaster Children's Hospital at Hamilton Health Sciences

Hamilton, Canada

Kingston Health Sciences Centre

Kingston, Canada

Children's Hospital

London, Canada

Children's Hospital of Eastern Ontario

Ottawa, Canada

Hospital for Sick Children

Toronto, Canada

The Montreal Children's Hospital of the MUHC

Montreal, Canada

Centre Hospitalier Universitaire Sainte-Justine

Montreal, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Canada

Jim Pattison Children's Hospital

Saskatoon, Canada

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)

Québec, Canada

University Pediatric Hospital

San Juan, Puerto Rico

Trial contact

Matthew A. Kutny

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Hamayun Imran

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Joseph C. Torkildson

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Etan Orgel

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Satiro N. De Oliveira

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Stephanie Mourad

PRINCIPAL_INVESTIGATOR

Monia Marzouki

PRINCIPAL_INVESTIGATOR

Josee Brossard

PRINCIPAL_INVESTIGATOR

Kathleen Felton

PRINCIPAL_INVESTIGATOR

Bruno Michon

PRINCIPAL_INVESTIGATOR

Site Public Contact

Maria E. Echevarria

PRINCIPAL_INVESTIGATOR

Contact information from ClinicalTrials.gov. Contact in English.

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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/17/2026.

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