Testing the Addition of an Anti-cancer Drug, Lenalidomide, to the Usual Combination Chemotherapy Treatment ("EPOCH") for Adult T-Cell Leukemia-Lymphoma (ATLL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial studies the side effects and best dose of lenalidomide when given together with usual combination chemotherapy (etoposide, prednisone, vincristine sulfate \[Oncovin\], cyclophosphamide, and doxorubicin hydrochloride \[hydroxydaunorubicin hydrochloride\], or "EPOCH") in treating adult T-cell leukemia-lymphoma. Lenalidomide may help shrink or slow the growth of adult T-cell leukemia-lymphoma. Drugs used in chemotherapy, such as etoposide, vincristine, cyclophosphamide, and doxorubicin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Anti-inflammatory drugs such as prednisone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Giving lenalidomide and the usual combination chemotherapy may work better in treating adult T-cell leukemia-lymphoma compared to the usual combination chemotherapy alone.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rozpoznanie chłoniaka T-komórkowego (ATLL) - typu ostrą, przewlekłą lub z wysokim ryzykiem
- •Pacjenci wcześniej nieleczeni lub po maksymalnie jednym cyklu chemioterapii (EPOCH, CHOP lub CHOPE)
- •Potwierdzenie zakażenia wirusem HTLV-1 poprzez badania krwi
- •Wiek minimum 18 lat
- •Wystarczająca sprawność fizyczna do leczenia (stan ogólny pozwalający na chemioterapię)
✗ Disqualifies
- •Wiek poniżej 18 lat (brak danych bezpieczeństwa u dzieci)
- •Zbyt niskie liczby białych krwinek (poniżej 1000/mm³), chyba że powoduje je nowotwór
- •Zbyt niskie liczby płytek krwi (poniżej 100000/mm³) z przyczyn innych niż nowotwór
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (19)
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
NYU Langone Hospital - Long Island
Mineola, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
NYP/Weill Cornell Medical Center
New York, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Trial contact
Site Public Contact
Pamela B. Allen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Lee Ratner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Steven M. Horwitz
PRINCIPAL_INVESTIGATOR
Site Public Contact
Catherine S. Diefenbach
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Jennifer E. Amengual
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jia Ruan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jonathan E. Brammer
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bruce O. Hough
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/17/2026.
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