Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study investigates how well radium-223 works in treating patients with castration-resistant prostate cancer than has spread to the bones (bone metastases). Prostate cancer is the most common cancer in men and the second leading cause of cancer death. Furthermore, many men with notably advanced disease have been found to have abnormalities in DNA repair. The purpose of this research is to study the role of a DNA repair pathway in prostate cancer, specifically in response to administration of radium-223, an FDA-approved drug known to cause DNA damage to cancerous cells. Understanding how defects in the DNA repair pathway affects radium-223 treatment of prostate, may help doctors help plan effective treatment in future patients.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzona diagnoza raka prostaty
- •Rak prostaty oporny na kastrację hormonalną
- •Przerzuty do kości widoczne na zdjęciach
- •Objawy z powodu raka prostaty
- •Planowane leczenie lekiem rad-223
- •Poziom PSA co najmniej 10 ng/mL
- •Gotowość do uczestnictwa i wykonywania wizyt kontrolnych
✗ Disqualifies
- •Przerzuty do narządów wewnętrznych (płuca, wątroba, itp.)
- •Jednoczesne leczenie rad-223 z innymi chemioterapiami
- •Poprzednie leczenie lekiem rad-223
- •Poprzednie leczenie chemioterapią zawierającą platynę
- •Zbyt niskie liczby białych i czerwonych krwinek oraz płytek
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 12, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (4)
Johns Hopkins University
Baltimore, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Fred Hutch/University of Washington Cancer Consortium
Seattle, United States
University of Wisconsin-Madison
Madison, United States
Trial contact
Jane Romani
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/13/2026.
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