Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial investigates how well trastuzumab deruxtecan works alone or in combination with anastrozole in treating patients with HER2 low, hormone receptor positive breast cancer. Trastuzumab deruxtecan is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug called deruxtecan. Trastuzumab attaches to HER2 expressed at low levels on cancer cells in a targeted way and delivers deruxtecan to kill them. Anastrozole works by decreasing estrogen production and suppressing the growth of tumors that need estrogen to grow. This study is evaluating how effective trastuzumab deruxtecan is at treating hormone receptor positive cancer cells that have low levels of HER2 expressed on them when given alone or in combination with anastrozole.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowotwór piersi wczesnego stadium, który można operować, o wielkości powyżej 2 cm.
- •Pacjenci z przerzutami do węzłów chłonnych, ale bez rozsianego raka w organizmie.
- •Rak piersi z niskim poziomem białka HER2 (oznaczone 1+ lub 2+).
- •Rak piersi reagujący na hormony (HR-pozytywny).
- •Ogólny stan zdrowia pacjenta pozwala na uczestnictwo w badaniu (grupa 0 lub 1 wg skali ECOG).
- •Prawidłowa czynność serca.
- •Odpowiednia liczba płytek krwi.
- •Odpowiedni poziom hemoglobiny (czerwonych krwinek).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- November 10, 2025
- Sex
- No restrictions
Therapies / drugs in trial
Locations (9)
St. Joseph Heritage Healthcare
Fullerton, United States
Cancer Blood and Specialty Clinic
Los Alamitos, United States
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, United States
Torrance Memorial Physician Network / Cancer Care
Torrance, United States
PIH Health
Whittier, United States
Orlando Health, Inc. d/b/a Orlando Health UF Health Center
Orlando, United States
Ft. Wayne Medical Oncology and Hematology, Inc.
Fort Wayne, United States
Cancer Center of Kansas
Wichita, United States
Massachusetts General Hospital
Boston, United States
Trial contact
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.