Neoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Upper tract urothelial cancer (UTUC) is cancer in the lining of the kidney or ureter (the tube that drains the kidney). This type of cancer is rare and as a result, there are only a few studies that have looked at it. Standard of care for UTUC would be surgery followed by chemotherapy (adjuvant chemotherapy). However, we know from studies that have looked at cancer of the lining of the bladder, which is a similar cancer in many ways, that treating people with chemotherapy before surgery (neoadjuvant chemotherapy) can lead to longer survival compared to the standard of care. There are no studies to show this in UTUC. Neoadjuvant chemotherapy is thought to help improve survival by treating any cancer that may have spread from the original tumour but that is not visible yet on scans. This study would be the first clinical trial in Canada to evaluate the use of chemotherapy before surgery in this disease setting. Since UTUC is rare, the purpose of this study is to determine if it is possible to enrol enough patients to a trial looking at the use of chemotherapy before surgery.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Świeżo zdiagnozowany rak wyściółki moczowodu lub nerki widoczny na CT lub MRI
- •Wiek co najmniej 18 lat
- •Ogólny stan zdrowia pozwalający na operację usunięcia nerki/moczowodu
- •Ogólny stan zdrowia pozwalający na chemioterapię
- •Prawidłowe wyniki badań krwi i funkcji nerek
✗ Disqualifies
- •Rak rozszerzył się na inne części ciała (przerzuty)
- •Powiększone węzły chłonne widoczne na zdjęciach
- •Jednocześnie występujący rak pęcherza moczowego (mięśniowo-inwazyjny)
- •Tylko jedna nerka
- •Inny rak lub chemioterapia w ostatnich 2 latach
- •Problemy słuchu, neuropatia lub aktywna infekcja
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (2)
The Ottawa Hospital
Ottawa, Canada
University Health Network
Toronto, Canada
Trial contact
Emily Hickey
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/7/2026.
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