Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies how well temozolomide and radiation therapy work in treating patients with IDH wildtype historically lower grade gliomas or non-histological molecular glioblastomas. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The goal of this clinical research study is to compare receiving new radiation therapy doses and volumes to the prior standard treatment for patients with historically grade II or grade III IDH wild-type gliomas, which may now be referred to as IDH wildtype molecular glioblastomas at some institutions. Receiving temozolomide in combination with radiation therapy may also help to control the disease.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie glejaka II lub III stopnia typu IDH wildtype (w tym astrocytoma, oligodendroglioma i ich odmiany)
- •Wykonane badanie MRI mózgu z kontrastem po operacji
- •Ogólny stan zdrowia (skala Karnofsky'ego) >= 70 procent
- •Wyniki krwi w normie: liczba neutrofili >= 1500, płytki >= 100000, hemoglobina >= 10 g/dl
- •Prawidłowe wyniki testów wątroby i nerek
✗ Disqualifies
- •Przerzuty nowotworu do innych części ciała
- •Wcześniejszy nowotwór złośliwy (poza czerniakiem skóry) chyba że był >= 3 lata temu
- •Wcześniejsza radioterapia głowy lub szyi
- •Wcześniejsza chemioterapia lub radioterapia glejaka mózgu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
M D Anderson Cancer Center
Houston, United States
Trial contact
Debra N Yeboa
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/17/2026.
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