Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial is to find out the possible side effects of pembrolizumab and radiation therapy before and during surgery in treating patients with head and neck squamous cell cancer that remains despite treatment (persistent) or has come back (recurrent). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays or protons to kill tumor cells and shrink tumors. Giving pembrolizumab and radiation therapy before and during surgery may kill more tumor cells.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak płaskonabłonkowy głowy i szyi (jama ustna, gardło, krtań), który pozostał po leczeniu lub powrócił
- •Nowotwór możliwy do usunięcia chirurgicznie
- •Wiek co najmniej 18 lat
- •Dobra ogólna kondycja zdrowotna (status ECOG poniżej 2)
- •Prawidłowe wyniki badań krwi, nerek i wątroby
- •Przerwę co najmniej 2 tygodnie od poprzedniego leczenia
- •Możliwość i chęć wyrażenia świadomej zgody na udział w badaniu
- •Wyniki pomiarów guza z tomografii lub rezonansu magnetycznego
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Ohio State University Comprehensive Cancer Center
Columbus, United States
Trial contact
The Ohio State University Comprehensive Cancer Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.
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