RecruitingPhase I/IIEN originalLeukemia

A Study of BGB-11417 in Participants With Myeloid Malignancies

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The study will determine the safety, tolerability, recommended Phase 2 dose (RP2D) and preliminary efficacy of BGB-11417 as monotherapy and in combination with azacitidine in participants with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)or MDS/myeloproliferative neoplasm (MPN) .

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzona diagnoza białaczki szpikowej (nie białaczki promyelocytowej), zespołu mielodysplastycznego lub zespołu mielodysplastyczno-mieloproliferacyjnego
  • Ogólny stan zdrowia pozwalający na przyjęcie zabiegu (skala 0-2)
  • Prawidłowe funkcjonowanie nerek (wskaźnik przesączania ≥50 mL/min, lub 30-49 dla pacjentów w słabszym stanie)
  • Prawidłowe funkcjonowanie wątroby
  • Oczekiwana długość życia ponad 12 tygodni
  • Zdolność do uczestniczenia w badaniu

✗ Disqualifies

  • Diagnoza białaczki promyelocytowej
  • Poprzednia terapia inhibitorami BCL-2
  • Zaangażowanie układu nerwowego przez białaczkę
  • Pierwotna choroba mieloproliferacyjna taka jak mielofibrozja, nadpłytkowość samorództwu lub wieloczerwienkowatość
  • Historia wcześniejszych nowotworów (z pewnymi wyjątkami dla chorób przemienionych w białaczkę lub leczonych 2+ lata temu)

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 13, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (46)

City of Hope National Medical Center

Duarte, United States

Tampa General Hospital

Tampa, United States

Upmc Hillman Cancer Center(Univ of Pittsburgh)

Pittsburgh, United States

Md Anderson Cancer Center

Houston, United States

Medical College of Wisconsin

Milwaukee, United States

Concord Repatriation General Hospital

Concord, Australia

St George Hospital

Kogarah, Australia

Orange Health Hospital

Orange, Australia

Gold Coast University Hospital

Southport, Australia

Monash Health

Clayton, Australia

St Vincents Hospital Melbourne

Fitzroy, Australia

Austin Health

Heidelberg, Australia

The Alfred Hospital

Melbourne, Australia

Fiona Stanley Hospital

Murdoch, Australia

Linear Clinical Research

Nedlands, Australia

One Clinical Research

Nedlands, Australia

Peking University Peoples Hospital

Beijing, China

The First Hospital of Lanzhou University

Lanzhou, China

Guangdong Provincial Peoples Hospital

Guangzhou, China

Nanfang Hospital, Southern Medical University

Guangzhou, China

The Second Peoples Hospital of Shenzhen

Shenzhen, China

Henan Cancer Hospital

Zhengzhou, China

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Wuhan, China

The First Affiliated Hospital of Soochow University

Suzhou, China

The First Affiliated Hospital of Nanchang University Branch Donghu

Nanchang, China

West China Hospital, Sichuan University

Chengdu, China

Tianjin Medical University Cancer Institute and Hospital

Tianjin, China

The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, China

Hopital Claude Huriez Chu Lille

Lille, France

Hopital Larchet

Nice, France

Hopital Saint Louis

Paris, France

Universitaetsklinikum Leipzig Aor

Leipzig, Germany

Universitaetsklinikum Ulm

Ulm, Germany

Policlinico Sorsola Malpighi, Aou Di Bologna

Bologna, Italy

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst

Meldola, Italy

Niguarda Cancer Center Division of Hematology

Milan, Italy

North Shore Hospital

Auckland, New Zealand

Wellington Regional Hospital (Ccdhb)

Wellington, New Zealand

Samsung Medical Center

GangnamGu, South Korea

Severance Hospital Yonsei University Health System

SeodaemunGu, South Korea

Hospital de La Santa Creu I Sant Pau

Barcelona, Spain

Hospital Universitario de Salamanca

Salamanca, Spain

Hospital Universitario Virgen Del Rocio

Seville, Spain

Hospital Universitari I Politecnic La Fe

Valencia, Spain

Edinburgh Cancer Centre

Edinburgh, United Kingdom

The Christie Hospital

Greater Manchester, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.

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