PRophylactic Cerebral Irradiation or Active MAgnetic Resonance Imaging Surveillance in Small-cell Lung Cancer Patients (PRIMALung Study)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
In this phase III study, the primary objective is to test with a one-sided significance of 5% whether for the treatment of small cell lung cancer (SCLC) patients, brain MRI surveillance alone is non-inferior in terms of overall survival compared to prophylactic cranial irradiation (PCI) combined with brain MRI surveillance in the entire study population.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Potwierdzony rozpoznaniem raka płuc małokomórkowego
- •Ukończona chemioterapia i radioterapia zgodnie ze standardowym leczeniem
- •Brak progresji nowotworu po zakończeniu leczenia (potwierdzone badaniami)
- •Brak przerzutów do mózgu lub opon mózgowo-rdzeniowych
- •Maksymalnie 8 tygodni od ostatniej sesji chemioterapii do wpisania do badania
- •Dobry ogólny stan zdrowia (skala ECOG ≤2)
- •Prawidłowa funkcja nerek
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (55)
Medical University of Graz - Radio-oncology
Graz, Austria
Institut Jules Bordet
Anderlecht, Belgium
Universitair Ziekenhuis Antwerpen
Edegem, Belgium
AZ Groeninge Kortrijk - Campus Kennedylaan
Kortrijk, Belgium
C.H.U. Sart-Tilman
Liège, Belgium
Gasthuiszusters van Antwerpen - GasthuisZusters Antwerpen - Sint-Augustinus
Wilrijk, Belgium
Institut de Cancerologie de l Ouest (ICO) - Angers
Angers, France
Institut Sainte Catherine (UNICANCER)
Avignon, France
Centre D'Onco. & Radioth. De Haute Energie Du Pays Basque (UNICANCER)
Bayonne, France
Institut Bergonie (UNICANCER)
Bordeaux, France
Centre Francois Baclesse (CLCC) (UNICANCER)
Caen, France
Centre Hospitalier Metropole Savoie
Chambéry, France
Centre Hospitaliler Cholet
Cholet, France
Centre Hopitalier Intercommunal De Creteil
Créteil, France
CHU de Dijon - Centre Georges-Francois-Leclerc (UNICANCER)
Dijon, France
Centre Hospitalier Departemental Vendee (UNICANCER)
La Roche-sur-Yon, France
Centre Oscar Lambret
Lille, France
Centre Hospitalier Bretagne Sud - Site du Scorff
Lorient, France
Institut Paoli-Calmettes (UNICANCER)
Marseille, France
Institut du Cancer de Montpellier (UNICANCER)
Montpellier, France
Assistance Publique Hopitaux Paris- APHP - APHP Sorbonne Univ - Hopital la Pitie-Salpetriere
Paris, France
Institut Curie- Hopital de Paris
Paris, France
Centre Catalan d'Oncologie (UNICANCER)
Perpignan, France
Centre Catalan d'Oncologie
Perpignan, France
CHU de Lyon - Hopital Lyon Sud (UNICANCER)
Pierre-Bénite, France
Centre Henri Becquerel (UNICANCER)
Rouen, France
Hospi Grand Ouest - Clinique Mutualiste de l'Estuaire
Saint-Nazaire, France
CHU Saint-Etienne - Hopital Nord
Saint-Priest-en-Jarez, France
Institut de Cancerologie Strasbourg Europe (UNICANCER)
Strasbourg, France
Polyclinique de l'Ormeau
Tarbes, France
Institut de Cancerologie de Lorraine
Vandœuvre-lès-Nancy, France
Centre d'Oncologie Saint-Yves
Vannes, France
Gustave Roussy (UNICANCER)
Villejuif, France
IRCCS Azienda Ospedaliera Universitaria San Martino "IST" - IRCCS - AUO San Martino - IST
Genova, Italy
ULSS 9 Scaligera Veneto - Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital
Legnago, Italy
Fondazione IRCCS - Policlinico San Matteo
Pavia, Italy
ASST-Bergamo Ospedale Treviglio-Caravaggio
Treviglio, Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma
Verona, Italy
University Medical Center Groningen
Groningen, Netherlands
Medical University Of Gdansk
Gdansk, Poland
Regional Cancer Centre
Olsztyn, Poland
Hospital Universitario Badajoz
Badajoz, Spain
Hospital Insular De Gran Canaria
Las Palmas de Gran Canaria, Spain
Hospital Universitario Puerta De Hierro
Majadahonda, Spain
Inselspital
Bern, Switzerland
Reseau Hospitalier Neuchatelois - RHNe - La Chaux de Fonds
La Chaux-de-Fonds, Switzerland
Kantonsspital St Gallen
Sankt Gallen, Switzerland
UniversitaetsSpital Zurich
Zurich, Switzerland
University Hospitals Bristol NHS Foundation Trust - Bristol Haematology And Oncology Centre
Bristol, United Kingdom
NHS Lothian - Western General Hospital
Edinburgh, United Kingdom
Maidstone & Tunbridge Wells NHS Trust - Maidstone Hospital
Maidstone, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Nottingham University Hospitals NHS Trust - City Hospital
Nottingham, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust - Weston Park Hospital
Sheffield, United Kingdom
Royal Marsden Hospital - Sutton
Sutton, United Kingdom
Trial contact
EORTC Reception
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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