Testing the Addition of Duvelisib or CC-486 to the Usual Treatment for Peripheral T-Cell Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies the effect of duvelisib or CC-486 and usual chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone in treating patients with peripheral T-cell lymphoma. Duvelisib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as CC-486, cyclophosphamide, doxorubicin, vincristine, etoposide and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help find out if this approach is better or worse than the usual approach for treating peripheral T-cell lymphoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rozpoznaniem chłoniaka T-komórkowego (typu obwodowego) z pewnymi podtypami
- •Mierzalne rozmiary nowotworu w badaniach obrazowych
- •Brak wcześniejszego leczenia przeciwnowotworowego (oprócz sterydów)
- •Wiek co najmniej 18 lat
- •Ogólny stan zdrowia pozwalający na leczenie (skala ECOG 0-2)
- •Wystarczająca liczba płytek krwi (co najmniej 75 000/mm³)
- •Wystarczająca liczba białych krwinek (ANC co najmniej 1 000/mm³)
- •Brak ciąży i nieprzekarmnianie dziecka piersią
✗ Disqualifies
- •Wysokie stężenie markera CD30 (30% lub więcej komórek nowotworowych)
- •Inne podtypy chłoniaka T-komórkowego niezgodne z kryteriami włączenia
- •Transformacja chłoniaka z grzybicy na postać dużokomórkową
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 19, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (96)
University of Arkansas for Medical Sciences
Little Rock, United States
City of Hope Comprehensive Cancer Center
Duarte, United States
UC San Diego Moores Cancer Center
La Jolla, United States
Cedars-Sinai Medical Center
Los Angeles, United States
MedStar Georgetown University Hospital
Washington D.C., United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
Grady Health System
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Augusta University Medical Center
Augusta, United States
Northwestern University
Chicago, United States
University of Illinois
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, United States
AMG Libertyville - Oncology
Libertyville, United States
Memorial Hospital East
Shiloh, United States
Carle Cancer Center
Urbana, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
University of Kentucky/Markey Cancer Center
Lexington, United States
Our Lady of the Lake Physician Group
Baton Rouge, United States
University of Maryland/Greenebaum Cancer Center
Baltimore, United States
Dana-Farber Cancer Institute
Boston, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Essentia Health Cancer Center
Duluth, United States
Mayo Clinic in Rochester
Rochester, United States
Saint Luke's Hospital
Chesterfield, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Mercy Hospital Springfield
Springfield, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Nebraska Medicine-Bellevue
Bellevue, United States
Nebraska Medicine-Village Pointe
Omaha, United States
University of Nebraska Medical Center
Omaha, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Cooper Hospital University Medical Center
Camden, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Roswell Park Cancer Institute
Buffalo, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
NYP/Weill Cornell Medical Center
New York, United States
University of Rochester
Rochester, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Wilmot Cancer Institute at Webster
Webster, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Wake Forest University Health Sciences
Winston-Salem, United States
Miami Valley Hospital South
Centerville, United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Riverside Methodist Hospital
Columbus, United States
Grant Medical Center
Columbus, United States
Miami Valley Hospital
Dayton, United States
Premier Blood and Cancer Center
Dayton, United States
Dayton Physician LLC - Englewood
Dayton, United States
Miami Valley Hospital North
Dayton, United States
Delaware Health Center-Grady Cancer Center
Delaware, United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, United States
Miami Valley Cancer Care and Infusion
Greenville, United States
Greater Dayton Cancer Center
Kettering, United States
Upper Valley Medical Center
Troy, United States
University of Cincinnati Cancer Center-West Chester
West Chester, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, United States
Rhode Island Hospital
Providence, United States
Medical University of South Carolina
Charleston, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
Dartmouth Cancer Center - North
Saint Johnsbury, United States
University of Virginia Cancer Center
Charlottesville, United States
Fred Hutchinson Cancer Center
Seattle, United States
University of Washington Medical Center - Montlake
Seattle, United States
Providence Saint Mary Regional Cancer Center
Walla Walla, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, United States
Gundersen Lutheran Medical Center
La Crosse, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Marshfield Medical Center - Minocqua
Minocqua, United States
Marshfield Medical Center-Rice Lake
Rice Lake, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Marshfield Medical Center - Weston
Weston, United States
Trial contact
Neha Mehta-Shah, MD, MSCI
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/20/2026.
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