RecruitingPhase IIIEN original

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Rak płuca drobnokomórkowy rozpoznany w ciągu ostatnich 5 lat.
  • Przerzuty raka do mózgu o średnicy do 4 cm.
  • Przerzuty raka nie znajdują się blisko obszaru mózgu odpowiedzialnego za pamięć (hipokampa).
  • Całkowita objętość przerzutów w mózgu wynosi 30 cm sześciennych lub mniej.
  • Przerzuty rozpoznane za pomocą rezonansu magnetycznego (MRI) wykonanego niedawno.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 1, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (231)

Mayo Clinic Hospital in Arizona

Phoenix, United States

Kaiser Permanente-Anaheim

Anaheim, United States

Kaiser Permanente-Bellflower

Bellflower, United States

Kaiser Permanente Los Angeles Medical Center

Los Angeles, United States

Los Angeles General Medical Center

Los Angeles, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, United States

Kaiser Permanente-Ontario

Ontario, United States

UCHealth University of Colorado Hospital

Aurora, United States

UCHealth Memorial Hospital Central

Colorado Springs, United States

Memorial Hospital North

Colorado Springs, United States

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, United States

Smilow Cancer Hospital Care Center - Guilford

Guilford, United States

Smilow Cancer Center/Yale-New Haven Hospital

New Haven, United States

Yale University

New Haven, United States

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, United States

Beebe Medical Center

Lewes, United States

Delaware Clinical and Laboratory Physicians PA

Newark, United States

Helen F Graham Cancer Center

Newark, United States

Medical Oncology Hematology Consultants PA

Newark, United States

Christiana Care Health System-Christiana Hospital

Newark, United States

Beebe Health Campus

Rehoboth Beach, United States

Christiana Care Health System-Wilmington Hospital

Wilmington, United States

UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, United States

UF Health Cancer Institute - Gainesville

Gainesville, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, United States

Moffitt Cancer Center-International Plaza

Tampa, United States

Moffitt Cancer Center - McKinley Campus

Tampa, United States

Moffitt Cancer Center

Tampa, United States

Moffitt Cancer Center at Wesley Chapel

Wesley Chapel, United States

Emory University Hospital Midtown

Atlanta, United States

Emory University Hospital/Winship Cancer Institute

Atlanta, United States

Emory Saint Joseph's Hospital

Atlanta, United States

Northside Hospital

Atlanta, United States

Northside Hospital-Cherokee

Canton, United States

Northside Hospital-Forsyth

Cumming, United States

Memorial Health University Medical Center

Savannah, United States

Rush-Copley Medical Center

Aurora, United States

Centralia Oncology Clinic

Centralia, United States

Rush MD Anderson Cancer Center

Chicago, United States

University of Chicago Comprehensive Cancer Center

Chicago, United States

Carle at The Riverfront

Danville, United States

Cancer Care Specialists of Illinois - Decatur

Decatur, United States

Decatur Memorial Hospital

Decatur, United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, United States

Carle Physician Group-Effingham

Effingham, United States

Crossroads Cancer Center

Effingham, United States

Northwestern Medicine Cancer Center Delnor

Geneva, United States

Carle Physician Group-Mattoon/Charleston

Mattoon, United States

UC Comprehensive Cancer Center at Silver Cross

New Lenox, United States

Cancer Care Center of O'Fallon

O'Fallon, United States

HSHS Saint Elizabeth's Hospital

O'Fallon, United States

OSF Saint Francis Medical Center

Peoria, United States

Carle Cancer Center

Urbana, United States

The Carle Foundation Hospital

Urbana, United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, United States

IU Health West Hospital

Avon, United States

IU Health North Hospital

Carmel, United States

Goshen Center for Cancer Care

Goshen, United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, United States

IU Health Methodist Hospital

Indianapolis, United States

Mary Greeley Medical Center

Ames, United States

McFarland Clinic - Ames

Ames, United States

Baptist Health Lexington

Lexington, United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, United States

UofL Health Medical Center Northeast

Louisville, United States

Mary Bird Perkins Cancer Center

Baton Rouge, United States

Luminis Health Anne Arundel Medical Center

Annapolis, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, United States

MedStar Franklin Square Medical Center/Weinberg Cancer Institute

Baltimore, United States

UM Upper Chesapeake Medical Center

Bel Air, United States

Central Maryland Radiation Oncology in Howard County

Columbia, United States

University of Maryland Shore Medical Center at Easton

Easton, United States

UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, United States

TidalHealth Richard A Henson Cancer Institute

Ocean Pines, United States

TidalHealth Peninsula Regional

Salisbury, United States

Boston Medical Center

Boston, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, United States

McLaren Cancer Institute-Bay City

Bay City, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, United States

Trinity Health Medical Center - Brighton

Brighton, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, United States

Trinity Health Medical Center - Canton

Canton, United States

Caro Cancer Center

Caro, United States

Chelsea Hospital

Chelsea, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, United States

Wayne State University/Karmanos Cancer Institute

Detroit, United States

Weisberg Cancer Treatment Center

Farmington Hills, United States

McLaren Cancer Institute-Flint

Flint, United States

Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, United States

McLaren Cancer Institute-Lapeer Region

Lapeer, United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, United States

Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, United States

McLaren Cancer Institute-Macomb

Mount Clemens, United States

McLaren Cancer Institute-Central Michigan

Mount Pleasant, United States

McLaren Cancer Institute-Northern Michigan

Petoskey, United States

McLaren-Port Huron

Port Huron, United States

MyMichigan Medical Center Saginaw

Saginaw, United States

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, United States

MyMichigan Medical Center Tawas

Tawas City, United States

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, United States

Sanford Joe Lueken Cancer Center

Bemidji, United States

Minnesota Oncology - Burnsville

Burnsville, United States

Mercy Hospital

Coon Rapids, United States

Minnesota Oncology - Coon Rapids

Coon Rapids, United States

Fairview Southdale Hospital

Edina, United States

Minnesota Oncology - Edina

Edina, United States

Unity Hospital

Fridley, United States

Fairview Clinics and Surgery Center Maple Grove

Maple Grove, United States

Minnesota Oncology - Maple Grove

Maple Grove, United States

Minnesota Oncology Hematology PA-Maplewood

Maplewood, United States

Abbott-Northwestern Hospital

Minneapolis, United States

Monticello Cancer Center

Monticello, United States

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, United States

Regions Hospital

Saint Paul, United States

United Hospital

Saint Paul, United States

Lakeview Hospital

Stillwater, United States

Minnesota Oncology Hematology PA-Woodbury

Woodbury, United States

Saint Francis Medical Center

Cape Girardeau, United States

Parkland Health Center - Farmington

Farmington, United States

Freeman Health System

Joplin, United States

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, United States

Mercy Hospital Springfield

Springfield, United States

Missouri Baptist Medical Center

St Louis, United States

Missouri Baptist Sullivan Hospital

Sullivan, United States

BJC Outpatient Center at Sunset Hills

Sunset Hills, United States

Billings Clinic Cancer Center

Billings, United States

Benefis Sletten Cancer Institute

Great Falls, United States

Logan Health Medical Center

Kalispell, United States

Cooper Hospital University Medical Center

Camden, United States

Sands Cancer Center

Canandaigua, United States

Northwell Health/Center for Advanced Medicine

Lake Success, United States

Northern Westchester Hospital

Mount Kisco, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, United States

Upstate Cancer Center Radiation Oncology at Oswego

Oswego, United States

Wilmot Cancer Institute Radiation Oncology at Greece

Rochester, United States

University of Rochester

Rochester, United States

State University of New York Upstate Medical University

Syracuse, United States

Upstate Cancer Center at Hill Radiation Oncology

Syracuse, United States

Montefiore Medical Center-Einstein Campus

The Bronx, United States

Montefiore Medical Center-Weiler Hospital

The Bronx, United States

Montefiore Medical Center - Moses Campus

The Bronx, United States

Upstate Cancer Center at Verona

Verona, United States

Wilmot Cancer Institute at Webster

Webster, United States

Wake Forest University Health Sciences

Winston-Salem, United States

Sanford Bismarck Medical Center

Bismarck, United States

Sanford Broadway Medical Center

Fargo, United States

Sanford Roger Maris Cancer Center

Fargo, United States

UH Seidman Cancer Center at UH Avon Health Center

Avon, United States

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, United States

Case Western Reserve University

Cleveland, United States

Ohio State University Comprehensive Cancer Center

Columbus, United States

Riverside Methodist Hospital

Columbus, United States

Grant Medical Center

Columbus, United States

Delaware Health Center-Grady Cancer Center

Delaware, United States

Grady Memorial Hospital

Delaware, United States

UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, United States

Mercy Health - Perrysburg Hospital

Perrysburg, United States

Mercy Health - Saint Anne Hospital

Toledo, United States

University of Cincinnati Cancer Center-West Chester

West Chester, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Saint Luke's Cancer Center - Allentown

Allentown, United States

UPMC Altoona

Altoona, United States

UPMC-Heritage Valley Health System Beaver

Beaver, United States

Saint Luke's University Hospital-Bethlehem Campus

Bethlehem, United States

Carlisle Regional Cancer Center

Carlisle, United States

Christiana Care Health System-Concord Health Center

Chadds Ford, United States

Chambersburg Hospital

Chambersburg, United States

Geisinger Medical Center

Danville, United States

Saint Luke's Hospital-Anderson Campus

Easton, United States

Ephrata Cancer Center

Ephrata, United States

UPMC Hillman Cancer Center Erie

Erie, United States

Saint Vincent Hospital

Erie, United States

UPMC Cancer Center at UPMC Horizon

Farrell, United States

Adams Cancer Center

Gettysburg, United States

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, United States

Sechler Family Cancer Center

Lebanon, United States

Geisinger Medical Oncology-Lewisburg

Lewisburg, United States

UPMC Cancer Center - Monroeville

Monroeville, United States

Thomas Jefferson University Hospital

Philadelphia, United States

Jefferson Torresdale Hospital

Philadelphia, United States

Allegheny General Hospital

Pittsburgh, United States

UPMC-Magee Womens Hospital

Pittsburgh, United States

UPMC-Presbyterian Hospital

Pittsburgh, United States

UPMC-Saint Margaret

Pittsburgh, United States

UPMC-Shadyside Hospital

Pittsburgh, United States

UPMC-Passavant Hospital

Pittsburgh, United States

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, United States

Saint Luke's Hospital - Upper Bucks Campus

Quakertown, United States

Saint Luke's Hospital-Quakertown Campus

Quakertown, United States

Saint Luke's Hospital - Monroe Campus

Stroudsburg, United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, United States

Divine Providence Hospital

Williamsport, United States

WellSpan Health-York Cancer Center

York, United States

WellSpan Health-York Hospital

York, United States

UPMC Memorial

York, United States

McLeod Regional Medical Center

Florence, United States

Gibbs Cancer Center-Gaffney

Gaffney, United States

Self Regional Healthcare

Greenwood, United States

Gibbs Cancer Center-Pelham

Greer, United States

Spartanburg Medical Center

Spartanburg, United States

SMC Center for Hematology Oncology Union

Union, United States

Sanford Cancer Center Oncology Clinic

Sioux Falls, United States

Avera Cancer Institute

Sioux Falls, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, United States

MD Anderson in The Woodlands

Conroe, United States

UT MD Anderson Cancer Center

Houston, United States

MD Anderson West Houston

Houston, United States

UT MD Anderson - League City

League City, United States

MD Anderson in Sugar Land

Sugar Land, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

Langlade Hospital and Cancer Center

Antigo, United States

ThedaCare Regional Cancer Center

Appleton, United States

Gundersen Lutheran Medical Center

La Crosse, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, United States

Medical College of Wisconsin

Milwaukee, United States

Cancer Center of Western Wisconsin

New Richmond, United States

Drexel Town Square Health Center

Oak Creek, United States

Aspirus Cancer Care - James Beck Cancer Center

Rhinelander, United States

Aspirus Cancer Care - Stevens Point

Stevens Point, United States

Aspirus Regional Cancer Center

Wausau, United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, United States

University Health Network-Princess Margaret Hospital

Toronto, Canada

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)

Québec, Canada

Allan Blair Cancer Centre

Regina, Canada

Saskatoon Cancer Centre

Saskatoon, Canada

Trial contact

Aakash Batra

PRINCIPAL_INVESTIGATOR

Jason C. Ye

PRINCIPAL_INVESTIGATOR

Site Public Contact

Hsiang-Hsuan M. Yu

PRINCIPAL_INVESTIGATOR

Gena H. Volas-Redd

PRINCIPAL_INVESTIGATOR

Kalika P. Sarma

PRINCIPAL_INVESTIGATOR

Bryan A. Faller

PRINCIPAL_INVESTIGATOR

Vinai Gondi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kevin Shiue

PRINCIPAL_INVESTIGATOR

Irina Sparks

PRINCIPAL_INVESTIGATOR

Site Public Contact

Joseph J. Merchant

PRINCIPAL_INVESTIGATOR

Site Public Contact

Neal E. Dunlap

PRINCIPAL_INVESTIGATOR

Victor T. Lin

PRINCIPAL_INVESTIGATOR

Site Public Contact

Mark V. Mishra

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kamila Nowak Choi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Samir Narayan

PRINCIPAL_INVESTIGATOR

Michael M. Dominello

PRINCIPAL_INVESTIGATOR

Daniel Almquist

PRINCIPAL_INVESTIGATOR

Yan Ji

PRINCIPAL_INVESTIGATOR

Donald J. Jurgens

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Jay W. Carlson

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Justin Mann

PRINCIPAL_INVESTIGATOR

Michael D. Mix

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Christina K. Cramer

PRINCIPAL_INVESTIGATOR

Site Public Contact

Haley K. Perlow

PRINCIPAL_INVESTIGATOR

Kyle Wang

PRINCIPAL_INVESTIGATOR

Simeng Zhu

PRINCIPAL_INVESTIGATOR

Aruna C. Gowda

PRINCIPAL_INVESTIGATOR

Tyler Gunter

PRINCIPAL_INVESTIGATOR

Serah Choi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Amit B. Shah

PRINCIPAL_INVESTIGATOR

Fiori Alite

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Rajesh Bajaj

PRINCIPAL_INVESTIGATOR

Martin C. Tom

PRINCIPAL_INVESTIGATOR

Andrew J. Huang

PRINCIPAL_INVESTIGATOR

Joseph A. Bovi

PRINCIPAL_INVESTIGATOR

Andrew M. Baschnagel

PRINCIPAL_INVESTIGATOR

Site Public Contact

Michael W. Straza

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Isabelle Thibault

PRINCIPAL_INVESTIGATOR

Site Public Contact

Taskia Mir

PRINCIPAL_INVESTIGATOR

Site Public Contact

Vijayananda Kundapur

PRINCIPAL_INVESTIGATOR

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.