Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib, a type of tyrosine kinase inhibitor, blocks a protein called BTK, which may help keep cancer cells from growing. Giving venetoclax and rituximab may work better in treating patients with previously untreated Waldenstrom's macroglobulinemia than ibrutinib with rituximab or zanubrutinib alone.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza choroby Waldenstroma (WM) lub limfoplazmatycznego chłoniaka (LPL).
- •Choroba musi być wykrywalna, mierzona ilością białka IgM (przynajmniej 500 mg/dL).
- •Potrzeba leczenia z powodu objawów, takich jak: anemia, niski poziom płytek krwi, problemy z nerwami, wysokie stężenie białka, choroby nerek lub powiększone węzły chłonne/śledziona.
- •Niektórzy pacjenci mogą mieć objawy ogólne, jak: utrata wagi, gorączka, nocne poty, silne zmęczenie.
- •Badania potwierdzające obecny stan choroby muszą być wykonane w ciągu 28 dni przed włączeniem do badania.
- •Pacjenci muszą mieć ukończone 18 lat.
✗ Disqualifies
- •Pacjenci, którzy przyjmowali lub potrzebują przyjmować pewne inne leki (inhibitory lub aktywatory CYP3A, inhibitory P-gp) w ciągu 7 dni przed pierwszą dawką leku w badaniu.
- •Pacjenci, którzy wcześniej byli leczeni ogólnoustrojowo (systemowo).
- •Pacjenci, którzy przyjmowali Rituximab wcześniej, muszą mieć ostatnią dawkę co najmniej 6 miesięcy przed rozpoczęciem udziału w badaniu.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 30, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (135)
Banner University Medical Center - Tucson
Tucson, United States
University of Arizona Cancer Center-North Campus
Tucson, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, United States
UM Sylvester Comprehensive Cancer Center at Doral
Doral, United States
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, United States
Mayo Clinic in Florida
Jacksonville, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, United States
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, United States
Centralia Oncology Clinic
Centralia, United States
Carle at The Riverfront
Danville, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Carle Physician Group-Effingham
Effingham, United States
Crossroads Cancer Center
Effingham, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Loyola University Medical Center
Maywood, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Carle Cancer Center
Urbana, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
McFarland Clinic - Boone
Boone, United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, United States
McFarland Clinic - Jefferson
Jefferson, United States
McFarland Clinic - Marshalltown
Marshalltown, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health Medical Center - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health Medical Center - Canton
Canton, United States
Chelsea Hospital
Chelsea, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Hematology Oncology Consultants-Clarkston
Clarkston, United States
Newland Medical Associates-Clarkston
Clarkston, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, United States
Henry Ford Hospital
Detroit, United States
Cancer Hematology Centers - Flint
Flint, United States
Genesee Hematology Oncology PC
Flint, United States
Genesys Hurley Cancer Institute
Flint, United States
Hurley Medical Center
Flint, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Henry Ford Medical Center-Columbus
Novi, United States
Michigan Healthcare Professionals Pontiac
Pontiac, United States
Newland Medical Associates-Pontiac
Pontiac, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
MyMichigan Medical Center Saginaw
Saginaw, United States
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, United States
MyMichigan Medical Center Tawas
Tawas City, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Huron Gastroenterology PC
Ypsilanti, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Mercy Hospital
Coon Rapids, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Hennepin County Medical Center
Minneapolis, United States
Mayo Clinic in Rochester
Rochester, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Saint Francis Medical Center
Cape Girardeau, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Heartland Regional Medical Center
Saint Joseph, United States
Washington University School of Medicine
St Louis, United States
Mercy Hospital South
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Saint Vincent Frontier Cancer Center
Billings, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Memorial Sloan Kettering Commack
Commack, United States
Glens Falls Hospital
Glens Falls, United States
Memorial Sloan Kettering Westchester
Harrison, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
University of Rochester
Rochester, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
Southeastern Medical Oncology Center-Clinton
Clinton, United States
Levine Cancer Institute-Gaston
Gastonia, United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, United States
Atrium Health Union/LCI-Union
Monroe, United States
Strecker Cancer Center-Belpre
Belpre, United States
Adena Regional Medical Center
Chillicothe, United States
Mount Carmel East Hospital
Columbus, United States
Columbus Oncology and Hematology Associates Inc
Columbus, United States
Riverside Methodist Hospital
Columbus, United States
Grant Medical Center
Columbus, United States
The Mark H Zangmeister Center
Columbus, United States
Mount Carmel Health Center West
Columbus, United States
Doctors Hospital
Columbus, United States
Delaware Health Center-Grady Cancer Center
Delaware, United States
Grady Memorial Hospital
Delaware, United States
Dublin Methodist Hospital
Dublin, United States
Central Ohio Breast and Endocrine Surgery
Gahanna, United States
Mount Carmel Grove City Hospital
Grove City, United States
Fairfield Medical Center
Lancaster, United States
Saint Rita's Medical Center
Lima, United States
OhioHealth Mansfield Hospital
Mansfield, United States
Marietta Memorial Hospital
Marietta, United States
OhioHealth Marion General Hospital
Marion, United States
Knox Community Hospital
Mount Vernon, United States
Licking Memorial Hospital
Newark, United States
Newark Radiation Oncology
Newark, United States
Mercy Health - Perrysburg Hospital
Perrysburg, United States
Southern Ohio Medical Center
Portsmouth, United States
Mercy Health - Saint Vincent Hospital
Toledo, United States
Mercy Health - Saint Anne Hospital
Toledo, United States
Saint Ann's Hospital
Westerville, United States
Genesis Healthcare System Cancer Care Center
Zanesville, United States
Providence Cancer Institute Clackamas Clinic
Clackamas, United States
Providence Newberg Medical Center
Newberg, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Cancer Institute-Edmonds
Edmonds, United States
Swedish Cancer Institute-Issaquah
Issaquah, United States
Swedish Medical Center-First Hill
Seattle, United States
ThedaCare Regional Cancer Center
Appleton, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, United States
Gundersen Lutheran Medical Center
La Crosse, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Marshfield Medical Center - Minocqua
Minocqua, United States
Marshfield Medical Center-Rice Lake
Rice Lake, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Marshfield Medical Center - Weston
Weston, United States
Trial contact
Site Public Contact
Muhammad Husnain
PRINCIPAL_INVESTIGATOR
Site Public Contact
Georgios Pongas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Sikander Ailawadhi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Tareq Al baghdadi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Priyank P. Patel
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Patrick A. Hagen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Joseph J. Merchant
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Vijayalakshmi Donthireddy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
David M. King
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Jay W. Carlson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Patrick W. Cobb
PRINCIPAL_INVESTIGATOR
Site Public Contact
Maria L. Palomba
PRINCIPAL_INVESTIGATOR
Site Public Contact
Clive S. Zent
PRINCIPAL_INVESTIGATOR
Site Public Contact
Manisha Bhutani
PRINCIPAL_INVESTIGATOR
Site Public Contact
Samer S. Kasbari
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Aruna C. Gowda
PRINCIPAL_INVESTIGATOR
Site Public Contact
Charles W. Drescher
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bharadhwaj Kolipakkam
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Yazhini Vallatharasu
PRINCIPAL_INVESTIGATOR
Site Public Contact
David E. Marinier
PRINCIPAL_INVESTIGATOR
Site Public Contact
Adedayo A. Onitilo
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.