Local Consolidative Therapy and Durvalumab for Oligoprogressive and Polyprogressive Stage III NSCLC After Chemoradiation and Anti-PD-L1 Therapy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial finds out the effect of local consolidative therapy and durvalumab in treating patients with stage III non-small cell lung cancer that has 3 or fewer lesions of progression (oligoprogressive) and greater than 3 lesions of progression (polyprogressive) after chemoradiation and anti-PD-l1 therapy. Local consolidative therapy, such as surgery and/or radiation, after initial treatment may kill any remaining tumor cells. Immunotherapy with durvalumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving local consolidative therapy and durvalumab may help to control the disease.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak płuca III stopnia (bez mutacji EGFR, ALK, ROS1, RET lub MET w gruczolakoraku, gdzie dostępne są inne leczenia)
- •Wcześniejsze leczenie chemioradioterapią i durvalumabem
- •Choroba postępująca lub pozostała po leczeniu początkowym
- •Maksymalnie 3 ogniska progresji (grupa A) lub więcej niż 3 ogniska (grupa B)
- •Możliwość otrzymania napromieniowania na co najmniej jedno ognisko
- •Badania obrazowe (tomografia, PET-CT, MRI mózgu) wykonane w ciągu 28 dni przed włączeniem
- •Wiek co najmniej 18 lat
- •Zdolność do podpisania świadomej zgody
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
M D Anderson Cancer Center
Houston, United States
Trial contact
Joe Y Chang, MD,MS,PHD
Joe Y Chang, MD,MS,PHD
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/11/2026.
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