Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Cancer and treatment-related cognitive changes, such as thinking or remembering, hinder resumption of normal routine and roles and worsen quality of life. Older adults undergoing hematopoietic cell transplantation (HCT) are at high-risk for cognitive impairment. Age is a risk factor for Alzheimer's Dementia (AD) and the hematological malignancies leading to HCT. There are shared mechanisms and interactions between AD and cancer-related cognitive decline (CRCD). Physical activity improves cognitive function in older adults and survivors of other cancers. This study hypothesizes that increasing physical activity can also improve cognitive function in this vulnerable population. The study has two goals. The first is to adapt and test an evidence-based physical activity intervention, The Community Health Activities Model Program for Seniors II (CHAMPS II), in the HCT setting for adults 55 years and older. This will be done using semi-structured interview of up to 10 patients who have experienced the HCT process within the last 3 to 6 months with HCT care-team partners. The second goal will explore the prevalence and impact of AD-neuropathology and inflammation on cancer-related cognitive decline (CRCD) in older adults undergoing HCT.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 55 lat lub więcej
- •Rozpoznany nowotwór krwi (białaczka, chłoniak lub inne)
- •Planowany lub wykonany przeszczep komórek w ciągu ostatnich 3-6 miesięcy
- •Zdolność chodzenia na odległość 4 metrów (z pomocą lub bez)
- •Fluencja w angielskim (czytanie i rozmowa)
- •Podpisana świadoma zgoda na uczestnictwo
✗ Disqualifies
- •Ból w klatce piersiowej lub ciężkie problemy z oddychaniem podczas testów fizycznych
- •Brak zgody lekarza na uczestnictwo w ćwiczeniach fizycznych
- •Zawał serca w ostatnich 3 miesiącach (wymaga zaświadczenia kardiologa)
- •Niestabilna choroba serca (arytmia, blok przewodzenia, słaba funkcja serca)
Simplified criteria — AI translation
Trial details
- Minimum age
- 19 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
University of Nebraska Medical Center
Omaha, United States
Trial contact
Marcia M Free, BSN
Thuy Koll, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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