A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combinations, in participants with metastatic colorectal cancer (mCRC) whose tumors are biomarker positive as per treatment arm-specific definition. Eligible participants with mCRC will be enrolled into specific treatment arms based on their biomarker assay results.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rak jelita grubego (okrężnicy lub odbytnicy) z przerzutami
- •Wyniki testów genetycznych pokazujące określone mutacje w guzie
- •Ogólny stan zdrowia pozwalający na udział w badaniu (ECOG 0-1)
- •Oczekiwana długość życia co najmniej 3 miesiące
- •Mierzalna zmiana nowotworowa widoczna w badaniach obrazowych
- •Wystarczająca funkcja organów i układu krwiotwórczego
- •Zdolność do przestrzegania wymogów badania
✗ Disqualifies
- •Jednoczesny udział w innym badaniu klinicznym z lekami doświadczalnymi
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (84)
UAB Comprehensive Cancer Center
Birmingham, United States
Mayo Clinic Arizona
Phoenix, United States
City of Hope Comprehensive Cancer Center
Duarte, United States
cCare
Encinitas, United States
USC Norris Cancer Center
Los Angeles, United States
Cedars-Sinai Medical Center
Los Angeles, United States
UCLA
Los Angeles, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, United States
Stanford Cancer Center
Stanford, United States
University of Colorado Cancer Center
Aurora, United States
Rocky Mountain Cancer Centers, LLP
Lone Tree, United States
Yale Cancer Center
New Haven, United States
Eastern Ct Hema/Onco Assoc
Norwich, United States
Mayo Clinic in Florida
Jacksonville, United States
Moffitt Cancer Center
Tampa, United States
Illinois Cancer Specialists
Arlington Heights, United States
Mary Bird Perkins Cancer Ctr
Baton Rouge, United States
Massachusetts General Hospital
Boston, United States
Karmanos Cancer Institute
Detroit, United States
Mayo Clinic Rochester
Rochester, United States
New York Cancer & Blood Specialists - New Hyde Park
New Hyde Park, United States
New York Cancer and Blood Specialists-Central Park Hematology & Oncology
New York, United States
New York Cancer & Blood Specialists
Port Jefferson Station, United States
New York Cancer & Blood Specialists - Bronx
The Bronx, United States
Duke University Medical Center
Durham, United States
Hematology Oncology Salem
Salem, United States
UPMC - Hillman Cancer Center
Pittsburgh, United States
Sarah Cannon Research Institute / Tennessee Oncology
Nashville, United States
SCRI Oncology Partners
Nashville, United States
Vanderbilt University Medical Center
Nashville, United States
Texas Oncology - Northeast Texas
Denton, United States
Lumi Research
Kingwood, United States
Texas Oncology - Gulf Coast
Webster, United States
Swedish Cancer Inst.
Seattle, United States
Medical Oncology Associates
Spokane, United States
Peter Maccallum Cancer Centre
Melbourne, Australia
Princess Margaret Cancer Center
Toronto, Canada
Jewish General Hospital
Montreal, Canada
McGill University Health Center
Montreal, Canada
Herlev Hospital, Afdeling for Kræftbehandling, Center for Kræftforskning, Klinisk Forskningsenhed
Herlev, Denmark
Rigshospitalet, Onkologisk Klinik
København Ø, Denmark
Charité Universitätsmedizin Berlin
Berlin, Germany
Katholisches Klinikum Bochum gGmbH - St. Josef-Hospital
Bochum, Germany
Universitätsklinik Carl Gustav Carus der Technischen Universität Dresden
Dresden, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Asklepios Klinik Altona
Hamburg, Germany
SLK-Kliniken Heilbronn GmbH;Klinik für Innere Medizin III
Heilbronn, Germany
Klinikum der Universität München, Campus Großhadern
München, Germany
Universitätsklinikum Ulm
Ulm, Germany
Università degli Studi della Campania Luigi Vanvitelli
Naples, Italy
Istituto Scientifico Romagnolo Per Lo Studio E La Cura Dei Tumori IRST - PPDS
Meldola, Italy
Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy
Irccs Istituto Nazionale Dei Tumori (Int)
Milan, Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)
Milan, Italy
IRCCS Istituto Oncologico Veneto (IOV)
Padova, Italy
Uniwersyteckie Centrum Kliniczne, O?rodek Bada? Klinicznych Wczesnych Faz
Gdansk, Poland
Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii
Krakow, Poland
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, Poland
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie
Warsaw, Poland
National Cancer Center
Goyang-si, South Korea
Chonnam National University Hwasun Hospital
Jeollanam-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Hospital Universitario de Donostia
Donostia / San Sebastian, Spain
Hospital Universitario Puerta de Hierro - Majadahonda
Majadahonda, Spain
Vall d'Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, Spain
START Madrid-FJD, Hospital Fundacion Jimenez Diaz
Madrid, Spain
START Madrid. Centro Integral Oncologico Clara Campal
Madrid, Spain
Hospital Clínico Universitario de Valencia
Valencia, Spain
Hospital Clinico Universitario Lozano Blesa
Zaragoza, Spain
National Cheng Kung University Hospital
Tainan, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
National Taiwan University Hospital
Zhongzheng Dist., Taiwan
Addenbrookes Hospital
Cambridge, United Kingdom
Velindre Cancer Centre
Cardiff, United Kingdom
Royal Free Hospital
London, United Kingdom
Royal Marsden Hospital;Dept of Med-Onc
London, United Kingdom
Sarah Cannon Research Institute
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Royal Marsden Hospital
Sutton, United Kingdom
Trial contact
Reference Study ID Number: WO42758 https://forpatients.roche.com/ No attachments to email below.
Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.