A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a first-in-human (FIH), Phase 1 open-label, multicentre dose escalation study investigating AVA6000 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumours that are likely to be FAP positive. The study consists of an initial Phase 1a dose escalation portion and a subsequent Phase 1b dose expansion portion upon completion of the dose escalation portion.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent został w pełni poinformowany o badaniu i podpisał zgodę.
- •Kobieta lub mężczyzna w wieku co najmniej 18 lat.
- •Guz potwierdzony histologicznie lub cytologicznie, zaawansowany lub z przerzutami.
- •Rak gruczołów ślinowych, pęcherza, jajnika lub piersi - niezareagował na standardowe leczenie lub pacjent go nie toleruje.
- •Mięsak tkanek miękkich - pacjent nie był wcześniej leczony lub otrzymał mniej niż 150 mg/m² doksorubicyny.
- •Wysoko zróżnicowany mięsak - może mieć maksymalnie 1 poprzednie leczenie.
- •Pacjent wykazuje progresję choroby w ciągu 6 miesięcy przed badaniem (lub jest nowo zdiagnozowany).
- •Pacjent posiada mierzalną chorobę i dostarczył próbkę tkanki do badania.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- May 15, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (9)
Memorial Sloan Kettering Cancer Center
New York, United States
University of Texas MD Anderson Cancer Center
Houston, United States
Fred Hutchinson Cancer Center
Seattle, United States
The Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde
Glasgow, United Kingdom
St James's University Hospital, The Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
The Royal Marsden, NHS Foundation Trust
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
The Freeman Hospital, Newcastle-upon-Tyne NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Weston Park Cancer Centre, Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom
Trial contact
Avacta Life Sciences
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.