A Study of Ruxolitinib and Duvelisib in People With Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will test the safety of ruxolitinib, given at one dose that does not change, and duvelisib, given at different doses, to find out what effects, if any, the study treatment has on people with relapsed or refractory NK-cell or T-cell lymphoma. This study has three parts: dose escalation (Part 1), dose expansion (Part 2), and TFH/T-PLL cohort expansion (Part 3).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony patologicznie dojrzały chłoniak T-komórkowy
- •Pacjenci z chłoniakiem na skórze (CTCL) w stadium II lub wyższym, którzy nie reagują na co najmniej dwie poprzednie terapie (maksymalnie 15 pacjentów)
- •Dużokomórkowy chłoniak anaplastyczny wymagający wcześniejszego leczenia zawierającego brentuximab vedotin
- •Prolimfocytowe zapalenie T-komórkowe (pacjenci bez poprzedniego leczenia są dopuszczeni)
- •Inne specyficzne typy chłoniaków T-komórkowych i NK-komórkowych (wymaga co najmniej jednego poprzedniego leczenia)
- •Wiek co najmniej 18 lat
- •Stan ogólny pacjenta oceniony na poziomie 0-2 wg skali ECOG (pacjent zdolny do większości codziennych czynności)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (9)
University of Miami (Data Collection Only)
Miami, United States
Dana Farber Cancer Institute
Boston, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Commack (Limited Protocol Activities)
Commack, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, United States
Trial contact
Alison Moskowitz, MD
Steven Horwitz, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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