Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a gene transfer study for patients with a type of blood cancer called Acute Lymphoblastic Leukemia (ALL) that has come back or has not gone away after treatment. The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancers. This research study combines two different ways of fighting cancer: antibodies and T cells. Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer. T cells, also called T lymphocytes, are special infection-fighting blood cells that can kill other cells, including cells infected with viruses and tumor cells. Both antibodies and T cells have been used to treat patients with cancers. They have shown promise but have not been strong enough to cure most patients. For example, T lymphocytes can kill cancer cells but there normally are not enough of them to kill all the cancer cells. Some researchers have taken T cells from a person's blood, grown more of them in the laboratory and then given them back to the person. The antibody used in this study targets CD19, CD20 and CD22. This antibody sticks to ALL cells because of a substance on the outside of these cells called CD19, CD20 and/or CD22. For this study, the antibody to CD19, CD20 and CD22 has been changed so that instead of floating free in the blood, it is now joined to the T cells. When T-cells contain an antibody that is joined to them, they are called chimeric antigen receptor- T cells or CAR-T cells. In the laboratory, we have also found that T cells work better if we also add proteins that stimulate them. One such protein is called 4-1BB. Adding the 4-1BB molecule makes the cells grow better and last longer in the body, giving them a better chance of killing the leukemia cells. In this study we are going to attach the CD19/CD20/CD22 chimeric receptor that has 4-1BB added to the patient's T cells. We will then test how long the cells last. These T cells, called "TRICAR-ALL" T cells are investigational products not approved by the Food and Drug Administration (FDA) outside the context of a clinical trial.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie ostrego białaczenia limfoblastycznego typu B, które nie zniknęło po leczeniu lub wróciło, z obecnością markerów CD19, CD20 i/lub CD22
- •Wiek od 1 do 25 lat
- •Przewidywana długość życia co najmniej 8 tygodni
- •Waga co najmniej 10 kg
- •Pacjenci w wieku 18+ muszą móc wyrazić świadomą zgodę; dla dzieci wymagana jest zgoda opiekuna i ewentualnie zgoda samego dziecka
- •Przerwanie wszystkich leków przeciwnowotworowych z co najmniej kilkudniowym wyprzedzeniem przed pobraniem komórek
✗ Disqualifies
- •Poprzednia terapia komórkami CAR-T w ciągu ostatnich 30 dni
- •Immunoterapia skierowana na białaczkę w postaci przeciwciał w ciągu ostatnich trzech okresów półtrwania (lub 4 tygodni)
- •Stosowanie leków immunosupresyjnych mogących wpłynąć na funkcję komórek T
Simplified criteria — AI translation
Trial details
- Minimum age
- 12 Months
- Maximum age
- 25 Years
- Last updated (source)
- September 4, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Texas Children's Hospital
Houston, United States
Trial contact
Bahey Salem, MD
Nabil Ahmed, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/5/2026.
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