High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of intermittent high dose testosterone. This therapy may result in responses in tumors which are genetically unstable because of DNA repair deficiency and this is a prospective study to test that hypothesis
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie rak gruczołowy prostaty
- •Zastosowana terapia zmniejszająca testosteron (za pomocą leków lub zabiegu chirurgicznego)
- •Rak prostaty oporny na kastację (testosteron poniżej 50 ng/ml) z progresją choroby
- •Przerzuty raka widoczne w badaniach kostnych lub tomografii
- •Poprzednia terapia co najmniej jednym nowoczesnym lekiem hamującym receptory androgenowe
- •Bez objawów raka lub bardzo łagodne objawy
- •Ogólny stan zdrowia pozwalający na otrzymanie leczenia
- •Potwierdzenie mutacji w genach ATM, CDK12 lub CHEK2 w badaniu genetycznym
✗ Disqualifies
- •Jednoczesne leczenie innego rodzaju nowotworu
- •Drobnokomórkowy typ raka prostaty
- •Przerzuty raka do mózgu
- •Przerzuty raka do wątroby
- •Aktywne zapalenie wątroby lub ciężka choroba wątroby
- •Poważne choroby serca lub poprzedni zawał
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 23, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (17)
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, United States
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, United States
Orlando VA Medical Center, Orlando, FL
Orlando, United States
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, United States
Robley Rex VA Medical Center, Louisville, KY
Louisville, United States
Kansas City VA Medical Center, Kansas City, MO
Kansas City, United States
St. Louis VA Medical Center John Cochran Division, St. Louis, MO
St Louis, United States
Durham VA Medical Center, Durham, NC
Durham, United States
Salisbury W.G. (Bill) Hefner VA Medical Center, Salisbury, NC
Salisbury, United States
VA Portland Health Care System, Portland, OR
Portland, United States
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, United States
Memphis VA Medical Center, Memphis, TN
Memphis, United States
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, United States
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, United States
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, United States
William S. Middleton Memorial Veterans Hospital, Madison, WI
Madison, United States
Trial contact
Robert B Montgomery, MD
Elahe Mostaghel, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/24/2026.
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