Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal squamous dysplasia (ESD). This strategy leverages the 'EsophaCap', a swallowable, retrievable sponge, with subsequent evaluation of the sample using a novel molecular biomarker assay. This biomarker assay evaluates methylation levels in select genes, which have been shown to differ significantly between ESCC cases and controls in pilot studies. Detection of methylation markers highly associated with ESCC could help identify patients with concurrent ESCC or at high risk of imminently developing this condition. If successful, this strategy could result in a paradigm shift for esophageal cancer control strategies in Tanzania and other high-incidence ESCC regions.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Pacjent leczony w szpitalu Muhimbili w Tanzanii
- •Potwierdzony rak przełyku lub podejrzenie na raka przełyku wymagające badania endoskopowego
- •Możliwość połykania płynów
- •Dobry stan ogólny pozwalający na 20-minutową rozmowę (własną lub przez krewnego)
- •Chęć kontaktu telefonicznego lub osobistego w ciągu 7-10 dni po procedurze
- •Obywatel Tanzanii
- •Pisemna zgoda na uczestnictwo w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 23, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (2)
Muhimbili National Hospital (MNH)
Dar es Salaam, Tanzania
Muhimbili National Hospital (MNH)
Dar es Salaam, Tanzania
Trial contact
Geoffrey Buckle, MD, MPH
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/24/2026.
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