The Gut Microbiome and Immune Checkpoint Inhibitor Therapy in Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The microbiome has the potential to serve as a robust biomarker of clinical response to immunotherapy. Additionally, microbial manipulation, through diet, exercise, prebiotics, probiotics, or microbially-derived metabolites, may prove to be beneficial in promoting anti-tumor immune responses. However, large prospective studies in humans with longitudinal sample collection and standardized methods are needed to understand how microbiota and their byproducts affect cancer therapies, particularly among patients undergoing identical therapy but experiencing different outcomes. The proposed observational study builds upon these hypotheses by proposing a large cohort design to further assess the associations between the gut microbiota (composition and function), host immune system, and ICI treatment efficacy across multiple cancer types.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Brak objawów COVID-19 w momencie wyrażenia zgody
- •Rozpoznanie raka płuca, czerniaka, raka piersi lub raka nerki (stadium I-IV)
- •Planowane leczenie inhibitorem kontrolnego punktu immunologicznego (samodzielnie lub w połączeniu z innymi lekami)
- •Możliwość wyrażenia świadomej zgody i wypełniania ankiet w języku angielskim lub hiszpańskim
- •Możliwość dostarczania próbek kału do badań
✗ Disqualifies
- •Brak zdolności do podejmowania decyzji
- •Pozbawienie wolności
- •Ciąża
- •Aktywne przerzuty do mózgu
- •Wcześniejsze leczenie inhibitorem w warunkach niestandardowych lub w ramach innego badania klinicznego
- •Aktywny udział w innym badaniu immunoonkologicznym
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- April 27, 2022
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Baptist Health Clinical Research
Elizabethtown, United States
Trial contact
Hanane Arib, MS
Peter McCaffrey, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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