Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial evaluates the side effects and usefulness of axicabtagene clioleucel (a CAR-T therapy) and find out what effect, if any, it has on treating patients with HIV-associated aggressive B-cell non-Hodgkin lymphoma that has come back (relapsed) or not responded to treatment (refractory). T cells are infection fighting blood cells that can kill tumor cells. Axicabtagene ciloleucel consists of genetically modified T cells, modified to recognize CD-19, a protein on the surface of cancer cells. These CD-19-specific T cells may help the body's immune system identify and kill CD-19-positive B-cell non-Hodgkin lymphoma cells.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej w momencie wyrażenia zgody
- •Zdolność do zrozumienia badania i podpisania dokumentu zgody
- •Rozpoznany powracający lub oporny chłoniak B-komórkowy (m.in. DLBCL, chłoniak mediastinalny, białaczka folikularna)
- •Wcześniejsze leczenie chemią i lekiem rytuksymab lub podobnym, bez trwałej odpowiedzi
- •Potwierdzone widoczne ogniska nowotworu w badaniach obrazowych lub biopsji szpiku
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu
- •Prawidłowe funkcje nerek, wątroby i płuc
✗ Disqualifies
- •Brak danych w źródle
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 10, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (7)
City of Hope Comprehensive Cancer Center
Duarte, United States
University of Illinois at Chicago
Chicago, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Montefiore Medical Center - Moses Campus
The Bronx, United States
The Ohio state University
Columbus, United States
University of Pennsylvania / Abramson Cancer Center
Philadelphia, United States
Huntsman Cancer Institute, University of Utah
Salt Lake City, United States
Trial contact
Ariela Noy
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/11/2026.
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