The study is for patients with advanced melanoma who are eligible for standard therapy with Pembrolizumab.
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
This trial is no longer recruiting — here are similar active trials
Matched by cancer type/biomarker, currently recruiting.
This study, known as LUNAR-2, aims to investigate the effectiveness and safety of using TTFields, delivered by the NovoTTF-200T device, concomitantly administered with pembrolizumab and platinum-based chemotherapy for patients with advanced non-small cell lung cancer that has spread to other parts of the body. The primary goals of the study are to assess overall survival and progression-free survival. Secondary objectives include analyzing outcomes based on the specific histology (subtype) of the lung cancer.
The goal of this randomized, double-blind, multi-regional phase 3 study of cadonilimab combined with chemotherapy versus chemotherapy in combination with or without nivolumab for the first-line treatment of participants with HER2-negative, previously untreated, unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma trial is to compare OS between cadonilimab combined with chemotherapy and chemotherapy in combination with or without nivolumab in the ITT population.
Metastatic colorectal cancer or mCRC is a cancer that starts in the parts of the large intestine (the colon or rectum) and has already spread to other parts of the body. This cancer can be hard to treat because it can behave differently from one person to another. Over time, treatments may stop working, and side effects can build up. In later treatment stages, there are only a few standard medicine options available. Because of this, studies often look at both how long people live and how treatment affects quality of life. The main aim of this study is to see how long adults in Poland with mCRC live without their cancer getting worse (progression-free survival or PFS) when they receive fruquintinib after at least two previous treatments. Fruquintinib (TAK 113) is a medicine taken by mouth that is designed to slow tumor growth. Other aim is to find out how long adults in Poland with mCRC live while being treated with fruquintinib (overall survival or OS). The study also wants to record how fruquintinib is used in routine care in adults with mCRC in Poland (for example when treatment starts, changes in doses, and how long treatment continues). Another aim is to learn about people with mCRC, such as their medical history and past treatment as well as their quality of life while they are in the study. The study will look at data already existing in the participants' medical charts.
About the trial
Immunotherapy (IO), such as treatment with anti-PD-1, PD-L1, or CTLA-4 inhibitors, is a rapidly expanding treatment for multiple metastatic cancers with improved survival for certain cancers. However, the optimal duration of immunotherapies is currently unknown. Our hypothesis is that a reduced dose intensity of IO could be as effective as the current standard treatment in term of prevention of the disease progression. If proved right, this study will have a positive medico-economic impact by reduction of the costs associated with the treatment and the toxicity, and an increase of the patients' quality of life.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Podpisana zgoda na uczestnictwo w badaniu
- •Wiek 18 lat lub więcej
- •Zaawansowany nowotwór (potwierdzony badaniem histologicznym) - m.in. rak płuca, nerki, głowy i szyi, pęcherza moczowego, piersi, czerniak
- •Odpowiedź na leczenie immunologiczne (zmniejszenie guza o co najmniej 30% lub całkowite zniknięcie) utrzymywana przez co najmniej 6 miesięcy
- •Zdolność do kontynuacji tego samego leczenia immunologicznego
- •Ogólny stan zdrowia pozwalający na aktywne życie z minimalnymi ograniczeniami (ECOG ≤1)
- •Przystosowanie metod antykoncepcji dla kobiet w wieku rozrodczym i mężczyzn przez cały czas badania
- •Gotowość do uczestnictwa w badaniu i wykonywania wizyt kontrolnych
✗ Disqualifies
- •Czerniak z całkowitym zniknięciem guza
- •Rak nerki w dobrej prognozie leczony kombinacją leków celowanych i immunoterapii
- •Nowotwory krwi (białaczka, szpiczak, chłoniak)
- •Aktywna infekcja wymagająca leczenia
- •Uczestnictwo w innym badaniu klinicznym w ciągu ostatnich 30 dni
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (33)
Institut de cancérologie de l'Ouest
Angers, France
Clinique Sainte Catherine
Avignon, France
Centre Hospitalier de la Côte Basque
Bayonne, France
CHU Bordeaux - Hôpial Saint André
Bordeaux, France
CH Boulogne sur Mer
Boulogne-sur-Mer, France
Centre François Baclesse
Caen, France
Centre Jean Perrin
Clermont-Ferrand, France
Centre Hospitalier Intercommunal
Créteil, France
CHU Henri Mondor
Créteil, France
Centre Georges François Leclerc
Dijon, France
GH Mutualiste de Grenoble
Grenoble, France
CHD Vendée
La Roche-sur-Yon, France
Centre Oscar Lambret
Lille, France
Clinique Chenieux
Limoges, France
Hospices Civils de Lyon
Lyon, France
Centre Léon Bérard
Lyon, France
Centre Antoine Lacassagne
Nice, France
CHU Nîmes/Institut de cancérologie du Gard
Nîmes, France
Hôpital Saint Louis
Paris, France
Hôpital Cochin APHP
Paris, France
Hôpital Saint Antoine APHP
Paris, France
CHU Poitiers
Poitiers, France
Centre Eugene Marquis
Rennes, France
CHI Elbeuf
Saint-Aubin-lès-Elbeuf, France
Institut de cancérologie de l'Ouest
Saint-Herblain, France
Centre Hospitalier Mémorial de Saint-Lô
Saint-Lô, France
Clinique Mutualiste de l'Estuaire
Saint-Nazaire, France
ICANS
Strasbourg, France
Hôpital Foch
Suresnes, France
HIA Sainte Anne
Toulon, France
IUCT
Toulouse, France
CHU Bretonneau
Tours, France
Centre Gustave Roussy
Villejuif, France
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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