Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO

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About the trial

Immunotherapy (IO), such as treatment with anti-PD-1, PD-L1, or CTLA-4 inhibitors, is a rapidly expanding treatment for multiple metastatic cancers with improved survival for certain cancers. However, the optimal duration of immunotherapies is currently unknown. Our hypothesis is that a reduced dose intensity of IO could be as effective as the current standard treatment in term of prevention of the disease progression. If proved right, this study will have a positive medico-economic impact by reduction of the costs associated with the treatment and the toxicity, and an increase of the patients' quality of life.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • •Podpisana zgoda na uczestnictwo w badaniu
  • •Wiek 18 lat lub więcej
  • •Zaawansowany nowotwór (potwierdzony badaniem histologicznym) - m.in. rak płuca, nerki, głowy i szyi, pęcherza moczowego, piersi, czerniak
  • •Odpowiedź na leczenie immunologiczne (zmniejszenie guza o co najmniej 30% lub całkowite zniknięcie) utrzymywana przez co najmniej 6 miesięcy
  • •Zdolność do kontynuacji tego samego leczenia immunologicznego
  • •Ogólny stan zdrowia pozwalający na aktywne życie z minimalnymi ograniczeniami (ECOG ≤1)
  • •Przystosowanie metod antykoncepcji dla kobiet w wieku rozrodczym i mężczyzn przez cały czas badania
  • •Gotowość do uczestnictwa w badaniu i wykonywania wizyt kontrolnych

✗ Disqualifies

  • •Czerniak z całkowitym zniknięciem guza
  • •Rak nerki w dobrej prognozie leczony kombinacją leków celowanych i immunoterapii
  • •Nowotwory krwi (białaczka, szpiczak, chłoniak)
  • •Aktywna infekcja wymagająca leczenia
  • •Uczestnictwo w innym badaniu klinicznym w ciągu ostatnich 30 dni

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 17, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (33)

Institut de cancérologie de l'Ouest

Angers, France

Clinique Sainte Catherine

Avignon, France

Centre Hospitalier de la Côte Basque

Bayonne, France

CHU Bordeaux - Hôpial Saint André

Bordeaux, France

CH Boulogne sur Mer

Boulogne-sur-Mer, France

Centre François Baclesse

Caen, France

Centre Jean Perrin

Clermont-Ferrand, France

Centre Hospitalier Intercommunal

Créteil, France

CHU Henri Mondor

Créteil, France

Centre Georges François Leclerc

Dijon, France

GH Mutualiste de Grenoble

Grenoble, France

CHD Vendée

La Roche-sur-Yon, France

Centre Oscar Lambret

Lille, France

Clinique Chenieux

Limoges, France

Hospices Civils de Lyon

Lyon, France

Centre Léon Bérard

Lyon, France

Centre Antoine Lacassagne

Nice, France

CHU Nîmes/Institut de cancérologie du Gard

Nîmes, France

Hôpital Saint Louis

Paris, France

Hôpital Cochin APHP

Paris, France

Hôpital Saint Antoine APHP

Paris, France

CHU Poitiers

Poitiers, France

Centre Eugene Marquis

Rennes, France

CHI Elbeuf

Saint-Aubin-lès-Elbeuf, France

Institut de cancérologie de l'Ouest

Saint-Herblain, France

Centre Hospitalier Mémorial de Saint-Lô

Saint-Lô, France

Clinique Mutualiste de l'Estuaire

Saint-Nazaire, France

ICANS

Strasbourg, France

Hôpital Foch

Suresnes, France

HIA Sainte Anne

Toulon, France

IUCT

Toulouse, France

CHU Bretonneau

Tours, France

Centre Gustave Roussy

Villejuif, France

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.

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