Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a phase 1/2, multicenter, open-label study. The phase 1 portion is a dose escalation and expansion study of STK-012 as monotherapy and in combination therapy in patients with selected advanced solid tumors. The phase 2 portion is a randomized study of STK-012 in combination with standard of care (SoC) pembrolizumab, pemetrexed, and carboplatin versus SoC, in patients with first line, PD-L1 negative or STK11 mutated, non-squamous, non-small cell lung cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zaawansowane nowotwory lite (Faza 1) lub rak płuca (Faza 2).
- •Rak płuca niekomórkowy (NSCLC) w zaawansowanym stadium (IV) lub stadium IIIB/IIIC, gdy inne leczenie nie jest możliwe.
- •Rodzaj raka płuca inny niż rak płaskonabłonkowy.
- •Brak wcześniejszego leczenia systemowego zaawansowanego raka płuca.
- •Guz wykazuje niską ekspresję PD-L1 (poniżej 1%) lub mutację STK11.
- •Brak znanych mutacji genetycznych (np. EGFR, ALK), dla których istnieje standardowe leczenie.
✗ Disqualifies
- •Wcześniejsze leczenie lekami immunologicznymi.
- •Rzadkie typy nowotworów, np. z elementami raka drobnokomórkowego.
- •Radioterapia w ciągu ostatnich 7 dni przed podaniem leku.
- •Aktywne przerzuty do mózgu.
- •Znana zapalenie opon mózgowo-rdzeniowych spowodowane przez nowotwór.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (47)
University of Arizona Cancer Center
Tucson, United States
Beverly Hills Cancer Center
Beverly Hills, United States
Providence Medical Foundation
Fullerton, United States
UC San Diego Moores Cancer Center
La Jolla, United States
Cedars Sinai
Los Angeles, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, United States
Yale New Haven Hospital, Yale Cancer Center
New Haven, United States
Georgetown University
Washington D.C., United States
Winship Cancer Institute, Emory University
Atlanta, United States
University of Chicago
Chicago, United States
University of Maryland
Baltimore, United States
Massachusetts General Hospital
Boston, United States
Beth Israel Deaconess Medical Center
Boston, United States
Dana-Farber Cancer Institute
Boston, United States
HealthPartners Cancer Center at Regions Hospital
Saint Paul, United States
Northwell Health
Lake Success, United States
NYU Langone Health
New York, United States
Columbia University Irving Medical Center
New York, United States
Memorial Sloan-Kettering Cancer Center
New York, United States
Duke Cancer Center
Durham, United States
University Hospitals Cleveland
Cleveland, United States
The James Cancer Hospital and Solove Research Institute
Columbus, United States
Providence Cancer Institute
Portland, United States
Fox Chase Cancer Center
Philadelphia, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
Baptist Memorial Hospital Cancer Center
Memphis, United States
Sarah Cannon Research Institute - Nashville
Nashville, United States
Renovatio Clinical
El Paso, United States
Oncology Consultants
Houston, United States
Renovatio Clinical
The Woodlands, United States
NEXT Virginia
Fairfax, United States
Northwest Medical Specialties
Tacoma, United States
LTD High Technology Hospital Medcenter
Batumi, Georgia
Caraps Medline, Ltd (JSC VIAN)
Tbilisi, Georgia
Institute of Clinical Oncology (ICO)
Tbilisi, Georgia
Israel Georgian Medical Research Clinic Healthycore
Tbilisi, Georgia
START Dublin
Dublin, Ireland
St. James Hospital
Dublin, Ireland
Beaumont Hospital
Dublin, Ireland
University Hospital Galway
Galway, Ireland
Hospital Quirón Barcelona
Barcelona, Spain
START Rioja
Logroño, Spain
MD Anderson
Madrid, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain
Hospital Regional de Málaga
Málaga, Spain
Clinica Universidad de Navarra - Pamplona
Pamplona, Spain
Trial contact
Synthekine STK-012-101 Contact
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.