Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests whether the combination of nivolumab and ipilimumab is better than nivolumab alone to shrink tumors in patients with deficient mismatch repair system (dMMR) endometrial carcinoma that has come back after a period of time during which the cancer could not be detected (recurrent). Deoxyribonucleic acid (DNA) mismatch repair (MMR) is a system for recognizing and repairing damaged DNA. In 2-3% of endometrial cancers this may be due to a hereditary condition resulted from gene mutation called Lynch Syndrome (previously called hereditary nonpolyposis colorectal cancer or HNPCC). MMR deficient cells usually have many DNA mutations. Tumors that have evidence of mismatch repair deficiency tend to be more sensitive to immunotherapy. There is some evidence that nivolumab with ipilimumab can shrink or stabilize cancers with deficient mismatch repair system. However, it is not known whether this will happen in endometrial cancer; therefore, this study is designed to answer that question. Monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving nivolumab in combination with ipilimumab may be better than nivolumab alone in treating dMMR recurrent endometrial carcinoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rozpoznanie nawrotowego raka endometrium (cancer, który powrócił po okresie bez objawów)
- •Widoczne guzy można zmierzyć w badaniach obrazowych (CT lub MRI) albo guz jest obecny ale trudno mierzalny
- •Rak endometrium musi mieć defekt w systemie naprawy DNA - potwierdzone badaniem laboratoryjnym
- •Pacjent musi mieć wynik testu potwierdzający defekt naprawy DNA (badanie patologiczne lub genetyczne)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 14, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (137)
University of Alabama at Birmingham Cancer Center
Birmingham, United States
University Cancer and Blood Center LLC
Athens, United States
Augusta University Medical Center
Augusta, United States
Saint Alphonsus Cancer Care Center-Boise
Boise, United States
Saint Luke's Cancer Institute - Boise
Boise, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, United States
Saint Luke's Cancer Institute - Meridian
Meridian, United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, United States
Saint Luke's Cancer Institute - Nampa
Nampa, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
University of Illinois
Chicago, United States
Carle at The Riverfront
Danville, United States
Carle Physician Group-Effingham
Effingham, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Carle BroMenn Medical Center
Normal, United States
Carle Cancer Institute Normal
Normal, United States
Carle Cancer Center
Urbana, United States
IU Health North Hospital
Carmel, United States
Northwest Cancer Center - Crown Point
Crown Point, United States
Northwest Oncology LLC
Dyer, United States
Northwest Cancer Center - Hobart
Hobart, United States
Saint Mary Medical Center
Hobart, United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, United States
Saint Catherine Hospital
Indianapolis, United States
The Community Hospital
Munster, United States
Women's Diagnostic Center - Munster
Munster, United States
Northwest Cancer Center - Valparaiso
Valparaiso, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
Bronson Battle Creek
Battle Creek, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
Trinity Health Grand Rapids Hospital
Grand Rapids, United States
Bronson Methodist Hospital
Kalamazoo, United States
West Michigan Cancer Center
Kalamazoo, United States
Beacon Kalamazoo Cancer Center
Kalamazoo, United States
Trinity Health Muskegon Hospital
Muskegon, United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, United States
Corewell Health Reed City Hospital
Reed City, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, United States
Munson Medical Center
Traverse City, United States
University of Michigan Health - West
Wyoming, United States
Mercy Hospital
Coon Rapids, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Miller-Dwan Hospital
Duluth, United States
Fairview Southdale Hospital
Edina, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Essentia Health Sandstone
Sandstone, United States
Saint Francis Regional Medical Center
Shakopee, United States
Essentia Health Virginia Clinic
Virginia, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, United States
Washington University School of Medicine
St Louis, United States
Community Hospital of Anaconda
Anaconda, United States
Billings Clinic Cancer Center
Billings, United States
Saint Vincent Frontier Cancer Center
Billings, United States
Intermountain Health West End Clinic
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Logan Health Medical Center
Kalispell, United States
Community Medical Center
Missoula, United States
Nebraska Methodist Hospital
Omaha, United States
Women's Cancer Center of Nevada
Las Vegas, United States
University of New Mexico Cancer Center
Albuquerque, United States
Roswell Park Cancer Institute
Buffalo, United States
University of Rochester
Rochester, United States
State University of New York Upstate Medical University
Syracuse, United States
Wilmot Cancer Institute at Webster
Webster, United States
Duke University Medical Center
Durham, United States
Duke Women's Cancer Care Raleigh
Raleigh, United States
Essentia Health Cancer Center-South University Clinic
Fargo, United States
UHHS-Chagrin Highlands Medical Center
Beachwood, United States
Miami Valley Hospital South
Centerville, United States
Geauga Hospital
Chardon, United States
Good Samaritan Hospital - Cincinnati
Cincinnati, United States
Case Western Reserve University
Cleveland, United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, United States
Cleveland Clinic Foundation
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Hillcrest Hospital Cancer Center
Mayfield Heights, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor, United States
University Hospitals Parma Medical Center
Parma, United States
UH Seidman Cancer Center at Saint John Medical Center
Westlake, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
UPMC-Heritage Valley Health System Beaver
Beaver, United States
UPMC Hillman Cancer Center at Butler Health System
Butler, United States
UPMC Hillman Cancer Center - Passavant - Cranberry
Cranberry Township, United States
UPMC Hillman Cancer Center Erie
Erie, United States
UPMC Cancer Center at UPMC Horizon
Farrell, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, United States
IRMC Cancer Center
Indiana, United States
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, United States
UPMC Cancer Center at UPMC McKeesport
McKeesport, United States
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, United States
UPMC Hillman Cancer Center - Monroeville
Monroeville, United States
UPMC Hillman Cancer Center in Coraopolis
Moon Township, United States
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant, United States
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, United States
UPMC Cancer Center-Natrona Heights
Natrona Heights, United States
UPMC Hillman Cancer Center - New Castle
New Castle, United States
UPMC-Magee Womens Hospital
Pittsburgh, United States
UPMC-Saint Margaret
Pittsburgh, United States
UPMC-Mercy Hospital
Pittsburgh, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
UPMC-Passavant Hospital
Pittsburgh, United States
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, United States
UPMC Cancer Center at UPMC Northwest
Seneca, United States
UPMC Cancer Center-Washington
Washington, United States
UPMC West Mifflin-Cancer Center Jefferson
West Mifflin, United States
Women and Infants Hospital
Providence, United States
Parkland Memorial Hospital
Dallas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, United States
University of Virginia Cancer Center
Charlottesville, United States
Henrico Doctor's Hospital
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Cancer Institute-Edmonds
Edmonds, United States
Swedish Cancer Institute-Issaquah
Issaquah, United States
Fred Hutchinson Cancer Center
Seattle, United States
Swedish Medical Center-First Hill
Seattle, United States
Duluth Clinic Ashland
Ashland, United States
Northwest Wisconsin Cancer Center
Ashland, United States
Trial contact
Site Public Contact
Michael D. Toboni
PRINCIPAL_INVESTIGATOR
Site Public Contact
Dan S. Zuckerman
PRINCIPAL_INVESTIGATOR
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Pratima Chalasani
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Jessica E. Parker
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
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Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
David P. Bender
PRINCIPAL_INVESTIGATOR
Site Public Contact
Jason A. Chesney
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Leslie S. Bradford
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kathleen Y. Butler
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Adrianne Mallen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bret E. Friday
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Arwa M. Mohammad
PRINCIPAL_INVESTIGATOR
Site Public Contact
Premal H. Thaker
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Megan Petersen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Brent J. Tierney
PRINCIPAL_INVESTIGATOR
Site Public Contact
Nicola M. Spirtos
PRINCIPAL_INVESTIGATOR
Site Public Contact
Carolyn Y. Muller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Rachael Turner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mary J. Cunningham
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Angeles A. Secord
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Amy Armstrong
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael S. Guy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Shahzad Siddique
PRINCIPAL_INVESTIGATOR
Site Public Contact
Peter G. Rose
PRINCIPAL_INVESTIGATOR
Site Public Contact
Floor Backes
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christina Washington
PRINCIPAL_INVESTIGATOR
Site Public Contact
Katherine M. Moxley
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Alexander B. Olawaiye
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
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Site Public Contact
Site Public Contact
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Site Public Contact
Cara A. Mathews
PRINCIPAL_INVESTIGATOR
Site Public Contact
David S. Miller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Linda R. Duska
PRINCIPAL_INVESTIGATOR
Site Public Contact
Andrew S. Kennedy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/15/2026.
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