BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial studies the good and bad effects of the combination of drugs called cabozantinib and nivolumab in treating patients with melanoma or squamous cell head and neck cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help doctors determine how quickly patients can be divided into groups based on biomarkers in their tumors. A biomarker is a biological molecule found in the blood, other body fluids, or in tissues that is a sign of a normal or abnormal process or a sign of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. The two biomarkers that this trial is studying are "tumor mutational burden" and "tumor inflammation signature." Another purpose of this trial is to help doctors learn if cabozantinib and nivolumab shrink or stabilize the cancer, and whether patients respond differently to the combination depending on the status of the biomarkers.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony czerniak w stadium III lub IV, który nie nadaje się do leczenia chirurgicznego lub nawrotowy, albo czerniak nieutajony.
- •Potwierdzony rak płaskonabłonkowy głowy i szyi, który nawrócił i nie kwalifikuje się do leczenia z intencją wyleczenia (np. radioterapia, operacja) lub jest zaawansowany (przerzuty). Główny guz musi znajdować się w jamie ustnej, gardle środkowym, gardle dolnym lub krtani.
- •Choroba, którą można zmierzyć (widoczna w badaniach obrazowych).
- •Poprzednie leczenie z wykorzystaniem leków blokujących punkt kontrolny PD-1 nie powiodło się lub nastąpił nawrót choroby.
- •Pacjenci zakażeni wirusem HIV muszą być leczeni i mieć niewykrywalną wiremię.
- •Pacjenci z przewlekłym zakażeniem wirusem zapalenia wątroby typu B (WZW B) muszą mieć niewykrywalną wiremię WZW B.
- •Pacjenci z przebytym zakażeniem wirusem zapalenia wątroby typu C (WZW C) muszą mieć niewykrywalną wiremię WZW C.
✗ Disqualifies
- •Guz pierwotny zlokalizowany w nosogardzieli lub guz pierwotny o nieznanym pochodzeniu.
- •Aktywne zakażenie wymagające leczenia ogólnoustrojowego (z wyjątkiem WZW B, WZW C lub HIV, zgodnie z powyższym).
- •Problemy z sercem.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 7, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (223)
Mayo Clinic Hospital in Arizona
Phoenix, United States
University of Arkansas for Medical Sciences
Little Rock, United States
Tower Cancer Research Foundation
Beverly Hills, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles, United States
Cedars-Sinai Medical Center
Los Angeles, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Rocky Mountain Regional VA Medical Center
Aurora, United States
UCHealth Memorial Hospital Central
Colorado Springs, United States
Memorial Hospital North
Colorado Springs, United States
Poudre Valley Hospital
Fort Collins, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, United States
UCHealth Greeley Hospital
Greeley, United States
Medical Center of the Rockies
Loveland, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
Mayo Clinic in Florida
Jacksonville, United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, United States
Queen's Cancer Cenrer - POB I
Honolulu, United States
Queen's Medical Center
Honolulu, United States
Queen's Cancer Center - Kuakini
Honolulu, United States
Hawaii Cancer Care - Westridge
‘Aiea, United States
Saint Alphonsus Cancer Care Center-Boise
Boise, United States
Saint Luke's Cancer Institute - Boise
Boise, United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, United States
Saint Luke's Cancer Institute - Meridian
Meridian, United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, United States
Saint Luke's Cancer Institute - Nampa
Nampa, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, United States
Rush-Copley Medical Center
Aurora, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Illinois CancerCare-Carthage
Carthage, United States
Centralia Oncology Clinic
Centralia, United States
Northwestern University
Chicago, United States
University of Illinois
Chicago, United States
Carle at The Riverfront
Danville, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
Illinois CancerCare-Dixon
Dixon, United States
Carle Physician Group-Effingham
Effingham, United States
Crossroads Cancer Center
Effingham, United States
Illinois CancerCare-Eureka
Eureka, United States
Illinois CancerCare-Galesburg
Galesburg, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
Illinois CancerCare-Kewanee Clinic
Kewanee, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, United States
Illinois CancerCare-Macomb
Macomb, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Loyola University Medical Center
Maywood, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
Northwestern Medicine Orland Park
Orland Park, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Illinois CancerCare-Princeton
Princeton, United States
Memorial Hospital East
Shiloh, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Carle Cancer Center
Urbana, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
Illinois CancerCare - Washington
Washington, United States
Rush-Copley Healthcare Center
Yorkville, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
McFarland Clinic - Boone
Boone, United States
Mercy Hospital
Cedar Rapids, United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, United States
Mercy Cancer Center-West Lakes
Clive, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, United States
McFarland Clinic - Jefferson
Jefferson, United States
McFarland Clinic - Marshalltown
Marshalltown, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
Tufts Medical Center
Boston, United States
Baystate Medical Center
Springfield, United States
Tufts Medical Center Cancer Center Stoneham
Stoneham, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
University of Michigan Rogel Cancer Center
Ann Arbor, United States
Bronson Battle Creek
Battle Creek, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health Medical Center - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health Medical Center - Canton
Canton, United States
Chelsea Hospital
Chelsea, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Wayne State University/Karmanos Cancer Institute
Detroit, United States
OSF Saint Francis Hospital and Medical Group
Escanaba, United States
Weisberg Cancer Treatment Center
Farmington Hills, United States
Cancer Hematology Centers - Flint
Flint, United States
Genesee Hematology Oncology PC
Flint, United States
Genesys Hurley Cancer Institute
Flint, United States
Hurley Medical Center
Flint, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, United States
Trinity Health Grand Rapids Hospital
Grand Rapids, United States
Bronson Methodist Hospital
Kalamazoo, United States
West Michigan Cancer Center
Kalamazoo, United States
Beacon Kalamazoo Cancer Center
Kalamazoo, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Trinity Health Muskegon Hospital
Muskegon, United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Corewell Health Reed City Hospital
Reed City, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, United States
Munson Medical Center
Traverse City, United States
University of Michigan Health - West
Wyoming, United States
Huron Gastroenterology PC
Ypsilanti, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Minnesota Oncology - Burnsville
Burnsville, United States
Mercy Hospital
Coon Rapids, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, United States
Essentia Health Cancer Center
Duluth, United States
Fairview Southdale Hospital
Edina, United States
Essentia Health - Fosston
Fosston, United States
Unity Hospital
Fridley, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Saint John's Hospital - Healtheast
Maplewood, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Essentia Health - Park Rapids
Park Rapids, United States
Mayo Clinic in Rochester
Rochester, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Ridgeview Medical Center
Waconia, United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, United States
Saint Francis Medical Center
Cape Girardeau, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Mercy Hospital South
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Community Hospital of Anaconda
Anaconda, United States
Billings Clinic Cancer Center
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Logan Health Medical Center
Kalispell, United States
Community Medical Center
Missoula, United States
Nebraska Medicine-Bellevue
Bellevue, United States
Nebraska Medicine-Village Pointe
Omaha, United States
University of Nebraska Medical Center
Omaha, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
University of New Mexico Cancer Center
Albuquerque, United States
Northwell Health/Center for Advanced Medicine
Lake Success, United States
NYU Langone Hospital - Long Island
Mineola, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, United States
Southeastern Medical Oncology Center-Clinton
Clinton, United States
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, United States
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, United States
Sanford Bismarck Medical Center
Bismarck, United States
Essentia Health Cancer Center-South University Clinic
Fargo, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Essentia Health - Jamestown Clinic
Jamestown, United States
Miami Valley Hospital South
Centerville, United States
Premier Blood and Cancer Center
Dayton, United States
Miami Valley Hospital North
Dayton, United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, United States
Miami Valley Cancer Care and Infusion
Greenville, United States
Upper Valley Medical Center
Troy, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Saint Charles Health System
Bend, United States
Clackamas Radiation Oncology Center
Clackamas, United States
Providence Newberg Medical Center
Newberg, United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, United States
Providence Willamette Falls Medical Center
Oregon City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Thomas Jefferson University Hospital
Philadelphia, United States
Jefferson Torresdale Hospital
Philadelphia, United States
Asplundh Cancer Pavilion
Willow Grove, United States
Rapid City Regional Hospital
Rapid City, United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
Dartmouth Cancer Center - North
Saint Johnsbury, United States
Inova Alexandria Hospital
Alexandria, United States
Inova Schar Cancer Institute
Fairfax, United States
Inova Fair Oaks Hospital
Fairfax, United States
Inova Fairfax Hospital
Falls Church, United States
Centra Alan B Pearson Regional Cancer Center
Lynchburg, United States
Virginia Cancer Institute
Richmond, United States
VCU Massey Cancer Center at Stony Point
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
VCU Health Tappahannock Hospital
Tappahannock, United States
Duluth Clinic Ashland
Ashland, United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, United States
Gundersen Lutheran Medical Center
La Crosse, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Medical College of Wisconsin
Milwaukee, United States
Marshfield Medical Center - Minocqua
Minocqua, United States
ProHealth D N Greenwald Center
Mukwonago, United States
Cancer Center of Western Wisconsin
New Richmond, United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, United States
Marshfield Medical Center-Rice Lake
Rice Lake, United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, United States
Essentia Health Saint Mary's Hospital - Superior
Superior, United States
ProHealth Waukesha Memorial Hospital
Waukesha, United States
UW Cancer Center at ProHealth Care
Waukesha, United States
Marshfield Medical Center - Weston
Weston, United States
Trial contact
Site Public Contact
Arkadiusz Z. Dudek
PRINCIPAL_INVESTIGATOR
Site Public Contact
Omar T. Atiq
PRINCIPAL_INVESTIGATOR
Site Public Contact
Inderjit Mehmi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Poorva Vaidya
PRINCIPAL_INVESTIGATOR
Site Public Contact
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Stacey Parker-Brueggemann
PRINCIPAL_INVESTIGATOR
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Site Public Contact
Gregory A. Masters
PRINCIPAL_INVESTIGATOR
Site Public Contact
Elie G. Dib
PRINCIPAL_INVESTIGATOR
Site Public Contact
Charles W. Drescher
PRINCIPAL_INVESTIGATOR
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Prem Sobti
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
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Jacob Choi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ryan Nguyen
PRINCIPAL_INVESTIGATOR
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Joseph I. Clark
PRINCIPAL_INVESTIGATOR
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Brendan J. Knapp
PRINCIPAL_INVESTIGATOR
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Joseph J. Merchant
PRINCIPAL_INVESTIGATOR
Site Public Contact
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Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Deborah W. Wilbur
PRINCIPAL_INVESTIGATOR
Site Public Contact
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
John C. McCann
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Paul L. Swiecicki
PRINCIPAL_INVESTIGATOR
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Kathleen Y. Butler
PRINCIPAL_INVESTIGATOR
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Matthew L. Ryan
PRINCIPAL_INVESTIGATOR
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Daniel Almquist
PRINCIPAL_INVESTIGATOR
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Bret E. Friday
PRINCIPAL_INVESTIGATOR
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David M. King
PRINCIPAL_INVESTIGATOR
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Jay W. Carlson
PRINCIPAL_INVESTIGATOR
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Alissa S. Marr
PRINCIPAL_INVESTIGATOR
Site Public Contact
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Garrett T. Wasp
PRINCIPAL_INVESTIGATOR
Site Public Contact
Moises Harari-Turquie
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ruth A. White
PRINCIPAL_INVESTIGATOR
Site Public Contact
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Samer S. Kasbari
PRINCIPAL_INVESTIGATOR
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Tarek M. Sabagh
PRINCIPAL_INVESTIGATOR
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Vishnu Nagalapuram
PRINCIPAL_INVESTIGATOR
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Jennifer M. Johnson
PRINCIPAL_INVESTIGATOR
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Abdel-Ghani Azzouqa
PRINCIPAL_INVESTIGATOR
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Kathleen C. Kerrigan
PRINCIPAL_INVESTIGATOR
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Sekwon Jang
PRINCIPAL_INVESTIGATOR
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Andrew Poklepovic
PRINCIPAL_INVESTIGATOR
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Kareem H. Abdelhadi
PRINCIPAL_INVESTIGATOR
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David E. Marinier
PRINCIPAL_INVESTIGATOR
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Callisia N. Clarke
PRINCIPAL_INVESTIGATOR
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Timothy R. Wassenaar
PRINCIPAL_INVESTIGATOR
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Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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