A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby z zaawansowanym lub rozprzestrzenionym rakiem, który nie zareagował na standardowe leczenie lub dla którego nie ma dostępnych standardowych opcji.
- •Rak musi mieć cechę HER2 (w niektórych przypadkach dopuszczalny jest brak tej cechy).
- •W badaniu można uczestniczyć, jeśli choroba jest mierzalna.
- •Stan ogólny pacjenta pozwala na udział w badaniu (ocena ECOG 0-1).
- •Serce musi działać prawidłowo (wynik LVEF ≥ 50%).
- •Należy wyrazić pisemną zgodę na udział w badaniu.
- •Osoby z rakiem endometrium lub szyjki macicy, które już przeszły leczenie.
✗ Disqualifies
- •Problemy z sercem, takie jak niewydolność serca (klasy II-IV) lub poważne zaburzenia rytmu serca.
- •Przebyty zawał serca lub niestabilna dławica piersiowa w ciągu ostatnich 6 miesięcy.
- •Problemy z wątrobą, nerkami lub innymi organami, które nie pozwalają na bezpieczne podanie leku.
- •Znaczne problemy z płucami.
- •Niekontrolowane infekcje wymagające leczenia.
- •Aktywne przerzuty do mózgu.
- •Nieustępujące działania niepożądane po wcześniejszym leczeniu nowotworu.
- •Znana nadwrażliwość na lek lub jego składniki.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- January 28, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (102)
Helios Clinical Research
Cerritos, United States
California Research Institute
Los Angeles, United States
Sharp Memorial Hospital
San Diego, United States
Washington Cancer Institute at MedStar Washington Hospital Center
Washington D.C., United States
Advanced Research LLC
Coral Springs, United States
The Oncology Institute of Hope and Innovation
Lakeland, United States
D&H Cancer Research Center LLC
Margate, United States
HCA Mercy Hospital
Miami, United States
BRCR Medical Center Inc.
Plantation, United States
BRCR Medical Center Inc.
Tamarac, United States
Southeastern Regional Medical Center, LLC
Newnan, United States
Kapi'olani Medical Center for Women and Children
Honolulu, United States
University of Chicago
Chicago, United States
Women's Cancer Care
Covington, United States
Holy Cross Hospital
Silver Spring, United States
Massachusetts General Hospital
Boston, United States
Beth Israel Deaconess Medical Center
Boston, United States
Profound Research LLC/Michigan Hematology & Oncology Consultants
Dearborn, United States
David C. Pratt Cancer Center
St Louis, United States
Women's Cancer Center of Nevada
Las Vegas, United States
Northwell Health
Lake Success, United States
Laura & Isaac Perlmutter Cancer Center at NYC Langone Health
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
North Shore Hematology Oncology Associate P.C. DBA New York Cancer and Blood Specialists
Shirley, United States
Regional Medical Oncology Center
Wilson, United States
Gabrail Cancer Center
Canton, United States
University of Oklahoma
Oklahoma City, United States
Rittenhouse Hematology Oncology
Philadelphia, United States
Thomas Jefferson University
Philadelphia, United States
AHN West Penn Hospital
Pittsburgh, United States
Tennessee Oncology
Nashville, United States
Clinical Trial Network
Houston, United States
Oncology and Hematology of South Texas, PA
Laredo, United States
NEXT Virginia
Fairfax, United States
Swedish Cancer Institute
Seattle, United States
Scientia Clinical Research LTD
Randwick, Australia
Macquarie Clinical Trials Unit
Sydney, Australia
Integrated Clinical Oncology Network Pty Ltd (Icon)
South Brisbane, Australia
Monash Health
Melbourne, Australia
The first affiliated hospital of Bengbu medical college
Bengbu, China
Anhui provincial hospital
Hefei, China
The Second Hospital of Anhui Medical University
Hefei, China
Beijing Cancer Hospital
Beijing, China
Cancer Hospital Chinese Academy of Medical Science
Beijing, China
The First Hospital of Jilin University
Hongcun, China
Chongqing University Cancer Hospital
Chongqing, China
The First affiliated Hospital of Chongqing Medical University
Chongqing, China
The First affiliated hospital of Xiamen University
Xiamen, China
Gansu Provincial Maternity and Child-care Hospital
Lanzhou, China
Huizhou First Hospital
Guangzhou, China
Sun Yat-Sen Memorial Hospital of Zhongshan University
Guangzhou, China
The First affiliated hospital, Sun Yat-sen University
Guangzhou, China
Cancer Hospital of Guangxi Medical University
Nanning, China
The First people's hospital of Yulin
Yulin, China
Affiliated Hospital of Hebei University
Baoding, China
Henan cancer Hospital
Zhengzhou, China
Anyang Tumor Hospital
Anyang, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Union hospital Tongji Medical college Huazhong university of science and technology
Wuhan, China
Hunan Cancer Hospital
Changsha, China
Hunan People's Provincial Hospital
Changsha, China
Xiangya Hospital Central South University
Changsha, China
Changzhou Tumor Hospital
Changzhou, China
Affiliated Hospital of Jiangnan University
Wuxi, China
The Affiliated Hospital of Xuzhou Medical College
Xuzhou, China
Xuzhou Cancer Hospital
Xuzhou, China
Jiangxi maternal and child health hospital
Nanchang, China
The Third Hospital of Nanchang
Nanchang, China
Jilin Cancer Hospital
Changchun, China
Liaoning cancer hospital & Institute
Shenyang, China
The First Hospital of China Medical University
Shenyang, China
The First Affiliated Hospital Of Xi'an Jiaotong University
Xi'an, China
Central hospital affiliated to Shandong first medical university
Jinan, China
Jinan Central Hospital
Jinan, China
Shandong Cancer hospital & institute
Jinan, China
Affiliated hospital of Jining medical university
Jining, China
Linyi Tumor Hospital
Liaocheng, China
Zibo Central hospital
Zibo, China
Yantai Yuhuangding Hospital
Yantai, China
Fudan University
Shanghai, China
Shanghai Tenth people's Hospital
Shanghai, China
The Obstetrics & Gynecology Hospital Affiliated to Fudan University
Shanghai, China
Tianjin Medical university cancer institute & hospital
Tianjin, China
Yunnan Provincial Cancer Hospital
Kunming, China
1st affliated hospital of Zhejiang University
Hangzhou, China
The second affiliated hospital of Zhejiang University School of Medicine
Hangzhou, China
Women's hospital school of medicine Zhejiang University
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
BRCR Global Puerto Rico LLC.
Mayagüez, Puerto Rico
Seoul National University Bundang Hospital
Gyeonggi-do, South Korea
Samsung Medical Center
Seoul, South Korea
National Cancer Center
Gyeonggi-do, South Korea
Severance Hospital
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Taipei Veterans General Hospital
Taipei, Taiwan
Changhua Christian Hospital
Changhua, Taiwan
Taipei Medical University Hospital
Taipei, Taiwan
Taipei Medical University-Shuang Ho Hospital
Taipei, Taiwan
Mackay Memorial Hospital-Taipei
Taipei, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan
Trial contact
Britney Winterberger
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.