Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect of biomarkers of zanzalintinib administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) and in combination with docetaxel and prednisone in participants with advanced solid tumors. In addition, the study will evaluate the effect of multiple dose administration of zanzalintinib on the single-dose pharmacokinetics of sensitive CYP3A4, CYP2C9, CYP2C19, or CYP1A2 substrates in participants with advanced solid tumors. In the Expansion Stage, the safety and efficacy of zanzalintinib as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotwór litty, który nie może być całkowicie usunięty operacyjnie, jest zaawansowany lub rozprzestrzenił się na inne części ciała
- •Dla raka nerki bez wcześniejszego leczenia: nieoperacyjny zaawansowany rak nerki z komponentem jasnokomórkowym
- •Dla raka nerki po wcześniejszym leczeniu: zaawansowany rak nerki, który pogorszył się po poprzednim leczeniu kombinacyjnym
- •Dla raka prostaty: mężczyźni z rakiem prostaty, który rozprzestrzenił się na inne części ciała i pogorszył się po wcześniejszym leczeniu hormonalnym
- •Dla raka pęcherza moczowego: potwierdzony zaawansowany rak pęcherza moczowego, który pogorszył się po chemioterapii platyną
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (122)
Exelixis Clinical Site #67
Phoenix, United States
Exelixis Clinical Site #1
Tucson, United States
Exelixis Clinical Site #123
Palo Alto, United States
Exelixis Clinical Site #59
Santa Barbara, United States
Exelixis Clinical Site #87
Littleton, United States
Exelixis Clinical Site #62
New Haven, United States
Exelixis Clinical Site #49
Newark, United States
Exelixis Clinical Site #48
Celebration, United States
Exelixis Clinical Site #11
Gainesville, United States
Exelixis Clinical Site #78
Jacksonville, United States
Exelixis Clinical Site #47
Miami, United States
Exelixis Clinical Site #61
Plantation, United States
Exelixis Clinical Site #8
Tampa, United States
Exelixis Clinical Site #26
Chicago, United States
Exelixis Clinical Site #4
Indianapolis, United States
Exelixis Clinical Site #122
Louisville, United States
Exelixis Clinical Site #14
Baltimore, United States
Exelixis Clinical Site #7
Boston, United States
Exelixis Clinical Site #65
Detroit, United States
Exelixis Clinical Site #13
Detroit, United States
Exelixis Clinical Site #68
Rochester, United States
Exelixis Clinical Site #2
Omaha, United States
Exelixis Clinical Site #5
Omaha, United States
Exelixis Clinical Site #55
Las Vegas, United States
Exelixis Clinical Site #88
East Brunswick, United States
Exelixis Clinical Site #105
Hackensack, United States
Exelixis Clinical Site #60
New York, United States
Exelixis Clinical Site #6
New York, United States
Exelixis Clinical Site #76
Syracuse, United States
Exelixis Clinical Site #12
Durham, United States
Exelixis Clinical Site #10
Cleveland, United States
Exelixis Clinical Site #51
Portland, United States
Exelixis Clinical Site #104
Hershey, United States
Exelixis Clinical Site #98
Philadelphia, United States
Exelixis Clinical Site #32
Pittsburgh, United States
Exelixis Clinical Site #24
Pittsburgh, United States
Exelixis Clinical Site #9
Myrtle Beach, United States
Exelixis Clinical Site #3
Nashville, United States
Exelixis Clinical Site #46
Austin, United States
Exelixis Clinical Site #111
Dallas, United States
Exelixis Clinical Site #89
Dallas, United States
Exelixis Clinical Site #73
Irving, United States
Exelixis Clinical Site #50
Plano, United States
Exelixis Clinical Site #70
Tyler, United States
Exelixis Clinical Site #66
Charlottesville, United States
Exelixis Clinical Site #33
Milwaukee, United States
Exelixis Clinical Site #116
Albury, Australia
Exelixis Clinical Site #35
Birtinya, Australia
Exelixis Clinical Site #16
Brisbane, Australia
Exelixis Clinical Site #42
Saint Leonards, Australia
Exelixis Clinical Site #36
Sydney, Australia
Exelixis Clinical Site #94
Graz, Austria
Exelixis Clinical Site #31
Salzburg, Austria
Exelixis Clinical Site #29
Vienna, Austria
Exelixis Clinical Site #106
Wein, Austria
Exelixis Clinical Site #39
Anderlecht, Belgium
Exelixis Clinical Site #37
Kortrijk, Belgium
Exelixis Clinical Site #85
Besançon, France
Exelixis Clinical Site #96
Bordeaux, France
Exelixis Clinical Site #79
Caen, France
Exelixis Clinical Site #118
Clermont-Ferrand, France
Exelixis Clinical Site #109
Lyon, France
Exelixis Clinical Site #92
Marseille, France
Exelixis Clinical Site #64
Nice, France
Exelixis Clinical Site #83
Paris, France
Exelixis Clinical Site #91
Paris, France
Exelixis Clinical Site #80
Rennes, France
Exelixis Clinical Site #63
Saint-Herblain, France
Exelixis Clinical Site #75
Strasbourg, France
Exelixis Clinical Site #84
Vandœuvre-lès-Nancy, France
Exelixis Clinical Site #115
Villejuif, France
Exelixis Clinical Site #103
Essen, Germany
Exelixis Clinical Site #113
Hamburg, Germany
Exelixis Clinical Site #108
Heidelberg, Germany
Exelixis Clinical Site #82
Herne, Germany
Exelixis Clinical Site #93
Jena, Germany
Exelixis Clinical Site #112
München, Germany
Exelixis Clinical Site #102
Nürtingen, Germany
Exelixis Clinical Site #107
Trier, Germany
Exelixis Clinical Site #95
Tübingen, Germany
Exelixis Clinical Site #86
Beersheba, Israel
Exelixis Clinical Site #72
Haifa, Israel
Exelixis Clinical Site #52
Jerusalem, Israel
Exelixis Clinical Site #71
Petah Tikva, Israel
Exelixis Clinical Site #69
Tel Aviv, Israel
Exelixis Clinical Site #38
Ẕerifin, Israel
Exelixis Clinical Site #121
Ancona, Italy
Exelixis Clinical Site #117
Bologna, Italy
Exelixis Clinical Site #90
Florence, Italy
Exelixis Clinical Site #101
Milan, Italy
Exelixis Clinical Site #81
Milan, Italy
Exelixis Clinical Site #40
Naples, Italy
Exelixis Clinical Site #74
Ravenna, Italy
Exelixis Clinical Site #30
Grafton, New Zealand
Exelixis Clinical Site #45
Hamilton, New Zealand
Exelixis Clinical Site #20
Bydgoszcz, Poland
Exelixis Clinical Site #28
Gdansk, Poland
Exelixis Clinical Site #34
Otwock, Poland
Exelixis Clinical Site #54
Poznan, Poland
Exelixis Clinical Site #114
Wroclaw, Poland
Exelixis Clinical Site #41
Badajoz, Spain
Exelixis Clinical Site #53
Barcelona, Spain
Exelixis Clinical Site #15
Barcelona, Spain
Exelixis Clinical Site #27
Barcelona, Spain
Exelixis Clinical Site #120
L'Hospitalet de Llobregat, Spain
Exelixis Clinical Site #57
Madrid, Spain
Exelixis Clinical Site #43
Madrid, Spain
Exelixis Clinical Site #58
Madrid, Spain
Exelixis Clinical Site #77
Madrid, Spain
Exelixis Clinical Site #19
Madrid, Spain
Exelixis Clinical Site #100
Madrid, Spain
Exelixis Clinical Site #18
Pamplona, Spain
Exelixis Clinical Site #119
Santander, Spain
Exelixis Clinical Site #23
Seville, Spain
Exelixis Clinical Site #56
Valencia, Spain
Exelixis Clinical Site #25
Valencia, Spain
Exelixis Clinical Site #21
Chur, Switzerland
Exelixis Clinical Site #22
Sankt Gallen, Switzerland
Exelixis Clinical Site #44
Winterthur, Switzerland
Exelixis Clinical Site #110
Cambridge, United Kingdom
Exelixis Clinical Site #99
London, United Kingdom
Exelixis Clinical Site #97
Middlesex, United Kingdom
Trial contact
Exelixis Clinical Trials
Backup or International
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/6/2026.
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