Pembrolizumab Combined With Bevacizumab With or Without Agonist Anti-CD40 CDX-1140 for the Treatment of Patients With Recurrent Ovarian Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests whether pembrolizumab combined with bevacizumab with or without agonist anti-CD40 CDX-1140 works to shrink tumors in patients with ovarian cancer that has come back (recurrent). Anti-CD40 CDX-1140 works by stimulating certain immune cells within the tumor and, when combined with other immunotherapy treatments, may increase antitumor antibody production. Immunotherapy with monoclonal antibodies, such as pembrolizumab and bevacizumab, may help the body's immune system, and may interfere with the ability of tumor cells to grow and spread. Giving pembrolizumab and bevacizumab with anti-CD40 CDX-1140 may decrease symptoms, prolong survival, and improve quality of life in patients with ovarian cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Nawracający rak jajnika, jajowodu lub otrzewnej (tego rodzaju nowotwory już wróciły po wcześniejszym leczeniu)
- •Maksymalnie 4 poprzednie linie leczenia
- •Znany status genu BRCA
- •Spodziewana długość życia większa niż 6 miesięcy
- •Dobrze funkcjonujący układ immunologiczny i organy wewnętrzne (testy krwi i nerek w normie)
- •Możliwość zmierzenia guzów na badaniach obrazowych
- •Wyleczenie się z skutków ubocznych poprzednich terapii
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 14, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (2)
Roswell Park Cancer Institute
Buffalo, United States
M D Anderson Cancer Center
Houston, United States
Trial contact
Emese Zsiros
Emese Zsiros
PRINCIPAL_INVESTIGATOR
Amir A. Jazaeri
Amir A. Jazaeri
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/15/2026.
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