A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment for their cancer. The purpose of Part 2 of this study evaluates pirtobrutinib monotherapy in treatment-naïve participants with CLL/SLL with 17p deletions. Participation could last up to six years for Part 1. Participation could last up to 2 years for Part 2.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzana diagnoza białaczki limfocytowej lub chłoniaka limfocytowego wymagająca leczenia
- •Znany status mutacji 17p (Część 1) lub posiadanie tej mutacji (Część 2)
- •Ogólny stan zdrowia pacjenta na poziomie 0-2 (ocena ECOG)
- •Wystarczająca funkcja nerek (przefiltrowywanie ≥30 ml/min)
- •Wystarczająca liczba płytek krwi (≥50 na miliard/L) lub wyższa w przypadku zaangażowania szpiku
- •Wystarczająca liczba hemoglobiny (≥8 g/dL) lub wyższa w przypadku zaangażowania szpiku
- •Wystarczająca liczba neutrofili (≥0,75 na miliard/L) lub wyższa w przypadku zaangażowania szpiku
✗ Disqualifies
- •Transformacja białaczki w agresywniejszy typ chłoniaka (Richtera) lub zakaźenie wirusem HIV
- •Zaangażowanie centralnego układu nerwowego (mózg i rdzeń kręgowy)
- •Poważne problemy z nerkami, mózgiem, psychiką, hormonami lub systemem odpornościowym
- •Niekontrolowana autoimmunologiczna niedokrwistość lub małopłytkowość
- •Poważne choroby serca, w tym słaba funkcja skurczowa (<40%) lub zaburzenia rytmu serca
- •Aktywne zakaźenie wirusem hepatitis B lub C
- •Aktywne zakaźenie wirusowe, bakteryjne lub grzybiczne niekontrolowane leczeniem
- •Poważne problemy z wchłanianiem pokarmu w jelitach lub niekontrolowana choroba zapalna jelit
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (143)
Pacific Cancer Medical Center, Inc
Anaheim, United States
TOI Clinical Research
Cerritos, United States
Stanford School of Medicine-Cancer Clinical Trials Office
Palo Alto, United States
California Cancer Associates for Research and Excellence
San Marcos, United States
Florida Cancer Specialists
Fort Myers, United States
Cancer Specialists of North Florida -St Augustine
Saint Augustine, United States
Florida Cancer Specialists East
West Palm Beach, United States
Hematology Oncology Clinic
Baton Rouge, United States
Tulane Cancer Center Office of Clinical Research
New Orleans, United States
American Oncology Partners of Maryland, PA
Bethesda, United States
St. Vincent Frontier Cancer Center
Billings, United States
Cancer Care Associates of York
York, United States
Prisma Health Cancer Institute
Greenville, United States
Sarah Cannon Research Institute SCRI
Nashville, United States
Kelsey Research Foundation
Houston, United States
Lumi Research
Kingwood, United States
Virginia Cancer Institute
Richmond, United States
Medical Oncology Associates, PS
Spokane, United States
MultiCare Health System Institute for Research and Innovation
Spokane, United States
Alexander Fleming
Ciudad Autónoma de Buenos Aire, Argentina
Hospital Privado De Comunidad
Mar del Plata, Argentina
Clínica de Nefrología, Urología y Enfermedades Cardiovasculares
Santa Fe, Argentina
One Clinical Research
Nedlands, Australia
Western Health, Sunshine Hospital
St Albans, Australia
The Perth Blood Institute
West Perth, Australia
Hanusch Krankenhaus
Vienna, Austria
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
Leuven, Belgium
VITAZ
Sint-Niklaas, Belgium
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, Brazil
Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESP
Botucatu, Brazil
Hemocentro Unicamp
Campinas, Brazil
Hospital Uopeccan - Centro de Pesquisa Clinica
Cascavel, Brazil
Centro Integrado de Oncologia de Curitiba
Curitiba, Brazil
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer
Curitiba, Brazil
Instituto do Câncer - Hospital São Vicente de Paulo
Passo Fundo, Brazil
Centro Gaucho Integrado - Mae de Deus Center
Porto Alegre, Brazil
Hospital de Clínicas de Ribeirão Preto
Ribeirão Preto, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
Santo André, Brazil
Centro Integrado de Pesquisa Clinica
São José do Rio Preto, Brazil
Hospital BP
São Paulo, Brazil
Hospital da Clinicas da Faculdade de Medicina da USP
São Paulo, Brazil
Hospital Santa Marcelina
São Paulo, Brazil
Royal Victoria Hospital-Montreal
Montreal, Canada
Hopital de L'Enfant Jesus
Québec, Canada
Cancer Care Manitoba
Winnipeg, Canada
Inmunocel
Santiago, Chile
CeCim Biocinetic
Santiago, Chile
Sociedad de Investigaciones Médicas Limitada
Temuco, Chile
Centro de Investigaciones Clínicas Viña del Mar (CIC)
Viña del Mar, Chile
The Second Xiangya Hospital of Central South University
Changsha, China
Hunan Cancer Hospital
Changsha, China
Sun Yat-sen University Cancer Center
Guangzhou, China
Southern Medical University Nanfang Hospital
Guangzhou, China
Hainan General Hospital
Haikou, China
First Affiliated Hosp of College of Med, Zhejiang University
Hangzhou, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Anhui Provincial Hospital
Hefei, China
The Second Hospital of Anhui Medical University
Hefei, China
Jiangxi Provincial Cancer Hospital
Nanchang, China
Guangxi Medical University Affiliated Tumor Hospital
Nanning, China
Fudan University Shanghai Cancer Center
Shanghai, China
Blood Institute of the Chinese Academy of Medical science
Tianjin, China
Tianjin Medical University General Hospital
Tianjin, China
Affiliated Cancer Hospital of Xinjiang Medical University
Ürümqi, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Wu Han Tongji Hospital
Wuhan, China
The Fourth Affiliated Hospital Zhejiang University School of Medicine
Yiwu, China
Fakultni nemocnice Brno
Brno, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, Czechia
Fakultni Nemocnice Ostrava
Ostrava, Czechia
Fakultni Nemocnice Plzen
Pilsen, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia
Vseobecna fakultni nemocnice v Praze
Prague, Czechia
CHD Vendee
La Roche-sur-Yon, France
Centre Hospitalier du Mans
Le Mans, France
Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1)
Limoges, France
CHU de Nantes - Hotel Dieu
Nantes, France
Centre Antoine Lacassagne
Nice, France
Hopital de la Pitie Salpetriere
Paris, France
Centre Hospitalier Lyon Sud
Pierre-Bénite, France
Hôpital de Pontchaillou
Rennes, France
Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen
Rouen, France
CHRU De Tours
Tours, France
Gemeinschaftspraxis für Hämatologie und Onkologie (Gefos)
Dortmund, Germany
Onkologische Gemeinschaftspraxis / BAG
Dresden, Germany
Universitaetsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik 1
Dresden, Germany
Universitätsklinikum Ulm
Ulm, Germany
Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum
Debrecen, Hungary
Markusovszky Egyetemi Oktatokorhaz
Szombathely, Hungary
Hadassah Medical Center
Jerusalem, Israel
Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo
Alessandria, Italy
Policlinico Sant'Orsola Malpighi
Bologna, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
Meldola, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Istituto Europeo di Oncologia
Milan, Italy
Azienda Unita Sanitaria Locale di Reggio Emilia
Reggio Emilia, Italy
Kumamoto University Hospital
Kumamoto, Japan
Yamagata University Hospital
Yamagata, Japan
Dunedin Hospital
Dunedin, New Zealand
Waikato Hospital
Hamilton, New Zealand
Momentum Clinical Research
Newtown, New Zealand
Middlemore Clinical Trials
Papatoetoe, New Zealand
KO-MED Centra Kliniczne
Biała Podlaska, Poland
Szpital Uniwersytecki nr 1 im. Antoniego Jurasza
Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Pratia Onkologia Katowice
Katowice, Poland
Pratia MCM Krakow
Krakow, Poland
Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1
Lublin, Poland
AIDPORT Sp. z o.o.
Skórzewo, Poland
Uniwersytecki Szpital Kliniczny Klinika
Wroclaw, Poland
Inje Univ Busan Paik Hospital
Busan, South Korea
The Catholic University of Korea-Seoul St. Mary's Hospital
Seocho-Gu, South Korea
Seoul National University Hospital
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Clinic de Barcelona
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Spain
Hospital Universitario Infanta Leonor-INTERNAL MED
Madrid, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain
Hospital Costa Del Sol
Marbella, Spain
Clinica Universitaria De Navarra
Pamplona, Spain
Hospital De Navarra
Pamplona, Spain
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Chang Bing Show Chwan Memorial Hospital
Changhua, Taiwan
Chang Gung Memorial Hospital - Chiayi
Chiayi County, Taiwan
National Cheng-Kung Uni. Hosp.
Tainan, Taiwan
Koo Foundation Sun Yan-Sen Cancer Center
Taipei, Taiwan
Gazi University Faculty of Medicine
Ankara, Turkey (Türkiye)
9 Eylul University Hospital
Balçova, Turkey (Türkiye)
Ege Üniversitesi
Bornova, Turkey (Türkiye)
Istanbul University Istanbul Medicine Faculty
Faith, Turkey (Türkiye)
American Hospital
Istanbul, Turkey (Türkiye)
Acıbadem Maslak Hastanesi
Istanbul, Turkey (Türkiye)
Ankara University Medicine Hospital
Mamak, Turkey (Türkiye)
Bristol Haematology and Oncology Centre
Bristol, United Kingdom
HOPE Centre
Leicester, United Kingdom
St Bartholomew's Hospital
London, United Kingdom
Singleton Hospital
Swansea, United Kingdom
Trial contact
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Physicians interested in becoming principal investigators please contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/18/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.