EMR Versus ESD for Barrett's Neoplasia
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Rationale: The optimal technique for removal of visible dysplastic lesions in Barrett's esophagus remains controversial. Endoscopic mucosal resection (EMR) is safe, effective, easy to apply, and has been the most widely used technique since 2008. Endoscopic submucosal dissection (ESD) is a more controlled dissection method with potential improved efficacy, but at the cost of higher technical complexity. Objective: The investigators aim to compare EMR and ESD for removal of visible lesions in Barrett's esophagus. Study design: Randomized clinical trial Study population: Patients with Barrett's esophagus and a visible lesion with dysplasia and/or early cancer. Suspicion for submucosal invasion is an exclusion criterion. Intervention: Patients are randomized to receive either EMR or ESD, with follow-up and no ablation during 12 months after the resection. Main study endpoint: Primary endpoint is the proportion of patients with no evidence of residual or local recurrent neoplasia during 12 months follow-up after baseline.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Osoby powyżej 18. roku życia.
- •Choroba wrzodowa przełyku z widoczną zmianą przedrakową, która nie wygląda na głęboko naciekającą.
- •Zgoda na udział w badaniu i możliwość zrozumienia jego zasad.
- •Zgoda na ewentualne poddanie się obu metodom leczenia (EMR lub ESD).
✗ Disqualifies
- •Zmiany podejrzewane o głębokie naciekanie.
- •Niewyrównane zaburzenia krzepnięcia krwi lub bardzo niski poziom płytek krwi.
- •Choroba wrzodowa przełyku z żylakami.
- •Przewiduje się, że pacjent będzie żył krócej niż 2 lata.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (6)
Amsterdam University Medical Center
Amsterdam, Netherlands
Catharina Ziekenhuis
Eindhoven, Netherlands
University Medical Center Groningen
Groningen, Netherlands
St. Antonius Ziekenhuis
Nieuwegein, Netherlands
Erasmus Medical Center
Rotterdam, Netherlands
University Medical Center Utrecht
Utrecht, Netherlands
Trial contact
prof. dr. J. Bergman
dr. W. Curvers
prof. dr. W. Nagengast
prof. dr. B.L.A.M. Weusten
dr. A. Koch
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.
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