Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier opening with Exablate Model 4000 Type 2.0/2.1 for the treatment of NSCLC brain metastases in patients who are undergoing planned FDA approved, on-label systemic therapy utilizing immune checkpoint inhibitors.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Zgoda na uczestnictwo w badaniu
- •Rak płuca (NSCLC) z przerzutami do mózgu o rozmiarze co najmniej 0,5 cm
- •Zaplanowane leczenie immunologiczne
- •Dobry stan ogólny (ocena wydolności ≥70%)
- •U kobiet: potwierdzenie, że nie są w ciąży
- •Badania krwi w normie dla leczenia immunologicznego
✗ Disqualifies
- •Świeże krwawienie w mózgu
- •Wysokie ryzyko krwawienia w mózgu
- •Objawy zwiększonego ciśnienia wewnątrzczaszkowego
- •Leczenie Bevacizumabem lub innymi lekami zwiększającymi ryzyko krwawienia
- •Zaburzenia krzepnięcia krwi
- •Aktywne zapalenie wątroby (Hepatitis B lub C)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 100 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (13)
St. Joseph's Hospital and Medical Center
Phoenix, United States
Hoag Memorial Hospital Presbyterian
Newport Beach, United States
Miami Cancer Institute at Baptist Health
Miami, United States
Moffitt Cancer Center
Tampa, United States
University of Maryland
Baltimore, United States
Atrium Health Wake Forest Baptist
Winston-Salem, United States
Oregon Health & Science University
Portland, United States
Rhode Island Hospital
Providence, United States
Johnston Willis Hospital
Richmond, United States
Sunnybrook Research Institute
Toronto, Canada
Samsung Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Soeul, South Korea
Trial contact
Alyssa Voelker-Christy
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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