Combination of Abemaciclib and Endocrine Therapy in Hormone Receptor Positive HER2 Negative Locally Advanced or Metastatic Breast Cancer With Focus on Digital Side Effect Management
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The MINERVA Trial aims to evaluate safety, efficacy and quality of life (QoL) for the combination of Abemaciclib with an Aromatase Inhibitor or Fulvestrant in pre- and postmenopausal patients with metastatic hormone receptor positive HER2 negative breast cancer in the first line setting. Side effect monitoring and patient reported outcomes will be captured using the web- and app-based CANKADO digital health application. Via this user-friendly tool the patients can document their therapy side effects (e.g. diarrhea) and outcomes on a day-to-day basis. The capturing of side effects using the digital health application will be done additionally to the regular AE documentation. Furthermore, translational research objectives of this trial include the investigation of biomarkers (ct-DNA, germline DNA) to evaluate whether they can give insights into the reasons for response, intrinsic or acquired resistance to the combined endocrine
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku co najmniej 18 lat
- •Podpisana świadoma zgoda na udział w badaniu
- •Rak piersi z receptorami hormonalnymi dodatnimi (HR+) i bez nadekspresji HER2
- •Zaawansowana choroba miejscowo nawrotowa lub przerzuty, które nie można operować lub leczyć promieniowaniem
- •Wskazanie do leczenia endokrynologicznego
- •Ogólny stan zdrowia nie gorszy niż 2 w skali ECOG
- •Przerzuty do mózgu (jeśli obecne) muszą być ustabilizowane
- •Gotowość do uczestniczenia przez całą długość badania i przestrzegania procedur
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- May 16, 2025
- Sex
- Female only
Therapies / drugs in trial
Locations (54)
Kliniken Ostalb gkAöR
Aalen, Germany
Klinikum St. Marien Kommunalunternehmen - AöR Der Stadt Amberg
Amberg, Germany
Klinikum Aschaffenburg-Alzenau gGmbH
Aschaffenburg, Germany
Gemeinschaftspraxis Dr. Heinrich / Dr. Bangerter
Augsburg, Germany
Universitätsklinikum Augsburg A.d.ö.R
Augsburg, Germany
MediOnko-Institut GbR
Berlin, Germany
Hämatologikum Biberach
Biberach, Germany
Gynäkologisches Zentrum Bonn - Friedensplatz
Bonn, Germany
Studien GbR Braunschweig
Braunschweig, Germany
Hämato-Onkologische Praxis im Medicum
Bremen, Germany
St. Elisabeth-Krankenhaus GmbH
Cologne, Germany
Onkologisches Zentrum Donauwörth
Donauwörth, Germany
Gemeinschaftspraxis
Dresden, Germany
Onkozentrum Dresden
Dresden, Germany
MVZ Medical Center Düsseldorf GmbH
Düsseldorf, Germany
Universitätsklinikum Düsseldorf
Düsseldorf, Germany
Internistische Praxis Ehingen
Ehingen, Germany
Universitätsklinikum Erlangen
Erlangen, Germany
St. Antonius-Hospital
Eschweiler, Germany
Centrum für Hämatologie und Onkologie Bethanien
Frankfurt, Germany
Universitätsklinikum Freiburg
Freiburg im Breisgau, Germany
Krankenhäuser Landkreis Freudenstadt gGmbH
Freudenstadt, Germany
Internistische Gemeinschaftspraxis
Friedrichshafen, Germany
Klinikum Garmisch-Partenkirchen GmbH
Garmisch-Partenkirchen, Germany
Main-Kinzig-Kliniken gGmbH Gelnhausen
Gelnhausen, Germany
Gemeinschaftspraxis und Tagesklinik Halle
Halle, Germany
Albertinen-Krankenhaus
Hamburg, Germany
Sana Klinikum Hameln-Pyrmont
Hamelin, Germany
Frauenärzte am Bahnhofsplatz
Hildesheim, Germany
ViDia Christliche Kliniken Karlsruhe
Karlsruhe, Germany
Klinikum Kassel GmbH
Kassel, Germany
Klinikverbund Kempten-Oberallgäu gGmbH
Kempten, Germany
Klinikum Konstanz
Konstanz, Germany
ZAGO- Zentrum für ambulante gynäkologische Onkologie
Krefeld, Germany
Krankenhausgesellschaft St. Vincenz mbH
Limburg, Germany
Praxis für gynäkologische Onkologie / Prof. Dr. med. Ulrike Nitz / Raquel von Schumann
Mönchengladbach, Germany
Kliniken Ostalb gkAöR, Stauferklinikum Schwäbisch Gmünd
Mutlangen, Germany
LMU - Klinikum der Universität München
München, Germany
München Klinik gGmbH Harlaching
München, Germany
TZN-Tumorzentrum Niederrhein GmbH
Neuss, Germany
Klinikum Nürnberg Nord
Nuremberg, Germany
medius KLINIK NÜRTINGEN
Nürtingen, Germany
Praxis Dr. Guth
Plauen, Germany
Klinikum Ernst von Bergmann gGmbH
Potsdam, Germany
Klinikum Rheine
Rheine, Germany
GPR Gesundheits- und Pflegezentrum Rüsselsheim gGmbH
Rüsselsheim am Main, Germany
Diakoneo Diak-Klinikum Schwäbisch Hall gGmbH
Schwäbisch Hall, Germany
Clinical Research Stolberg GmbH
Stolberg, Germany
Gynäkologie Kompetenzzentrum Stralsund
Stralsund, Germany
Universitätsfrauenklinik Tübingen
Tübingen, Germany
University Hospital Ulm Gynecology/Obstetrics
Ulm, Germany
St. Josefs-Hospital
Wiesbaden, Germany
Spital Wallis
Brig, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Trial contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.