Study of Osimertinib With Carotuximab in Advanced, EGFR-mutated Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to examine the combination of osimertinib and carotuximab to assess the safety and find the recommended dose for treatment of advanced EGFR-mutated non-small cell lung cancer (NSCLC). Safety and tolerability will be measured by the number of dose-limiting toxicities, according to National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) Version 5, to find the maximum tolerated dose. The secondary objectives include evaluating the rate of objective response rate, duration of response, progression-free survival, and disease control rate, along with assessing biomarkers through tumor tissue and circulating tumor DNA.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zaawansowany rak płuca (stadium IV) lub nawrotowy z przerzutami, z mutacją genu EGFR
- •Wiek co najmniej 18 lat
- •Wcześniejsze leczenie co najmniej jednym lekiem z grupy inhibitorów EGFR bez efektu
- •Ogólny stan zdrowia pozwalający na leczenie (skala ECOG 0-2)
- •Zmierzytelne zmiany nowotworowe widoczne w badaniach obrazowych
- •Przerzuty do mózgu są dopuszczalne, jeśli pacjent nie ma objawów i stan jest stabilny
- •Ukończony poprzedni schemat chemioterapii lub radioterapii przed rozpoczęciem badania
- •Zgoda na użycie antykoncepcji oraz pisemna zgoda na udział w badaniu
✗ Disqualifies
- •Historia zapalenia tkanki płucnej (międzyzacierniowej) lub zapalenia spowodowanego lekami
- •Drobnokomórkowy rak płuca
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (5)
Cedars-Sinai Cancer at Beverly Hills (THO)
Beverly Hills, United States
Cedars-Sinai Cancer at The Angeles Clinic and Research Institute
Los Angeles, United States
Cedars-Sinai Cancer at SOCC
Los Angeles, United States
Cedars-Sinai Medical Center
Los Angeles, United States
Cedars-Sinai Cancer at Hunt Cancer Center - TMPNCC
Torrance, United States
Trial contact
Clinical Trial Recruitment Navigator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/7/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.